The University of Southampton
University of Southampton Institutional Repository

Haste makes waste: are the data regarding TARGIT-A IORT ready for prime time?

Haste makes waste: are the data regarding TARGIT-A IORT ready for prime time?
Haste makes waste: are the data regarding TARGIT-A IORT ready for prime time?
We would like to comment on the manuscript written by Esserman and colleagues [1] regarding the application of a decision analytic framework for adoption of clinical trial results. It is true that due to the prevalence of breast cancer, any management decision concerning its treatment may have significant implications concerning medical resources use and costs. However, this also holds true for any mistake or hasty decision that might carry a heavy price on public health in the long term.

If the purpose of the model presented in the article aimed to describe an analytic framework, then for the purpose of proof of concept, the statistical analysis should be applied first on treatments for which long-term follow-up is available, in order to prove and validate that the model can predict the same results as in the reality of daily practice. The use of the currently available TARGIT-A trial data to evaluate this model is inappropriate since follow-up in the TARGIT-A trial is immature [2, 3]

0167-6806
Kaidar-Person, Orit
607d878b-368f-4bb1-960f-55a91a001599
Poortmans, Philip
c0ccb9f2-3a10-4469-b2a2-1db18b7c4c29
Klimberg, Suzanne
afe3e389-f678-42e2-85f8-39f9ae44ba31
Haviland, Joanne
569aa43b-15bd-4e9d-b4a5-e68a84334cfe
Offersen, Birgitte
7f93e017-044a-48b5-8ffb-6440bafb99a6
Audisio, Riccardo
1b0abc51-376f-4e5d-9572-9d6bd0436c4e
Yarnold, John
16e929ca-7e4b-41b4-967c-2ead0e634ca1
Kaidar-Person, Orit
607d878b-368f-4bb1-960f-55a91a001599
Poortmans, Philip
c0ccb9f2-3a10-4469-b2a2-1db18b7c4c29
Klimberg, Suzanne
afe3e389-f678-42e2-85f8-39f9ae44ba31
Haviland, Joanne
569aa43b-15bd-4e9d-b4a5-e68a84334cfe
Offersen, Birgitte
7f93e017-044a-48b5-8ffb-6440bafb99a6
Audisio, Riccardo
1b0abc51-376f-4e5d-9572-9d6bd0436c4e
Yarnold, John
16e929ca-7e4b-41b4-967c-2ead0e634ca1

Kaidar-Person, Orit, Poortmans, Philip, Klimberg, Suzanne, Haviland, Joanne, Offersen, Birgitte, Audisio, Riccardo and Yarnold, John (2014) Haste makes waste: are the data regarding TARGIT-A IORT ready for prime time? Breast Cancer Research and Treatment. (doi:10.1007/s10549-014-3032-5).

Record type: Article

Abstract

We would like to comment on the manuscript written by Esserman and colleagues [1] regarding the application of a decision analytic framework for adoption of clinical trial results. It is true that due to the prevalence of breast cancer, any management decision concerning its treatment may have significant implications concerning medical resources use and costs. However, this also holds true for any mistake or hasty decision that might carry a heavy price on public health in the long term.

If the purpose of the model presented in the article aimed to describe an analytic framework, then for the purpose of proof of concept, the statistical analysis should be applied first on treatments for which long-term follow-up is available, in order to prove and validate that the model can predict the same results as in the reality of daily practice. The use of the currently available TARGIT-A trial data to evaluate this model is inappropriate since follow-up in the TARGIT-A trial is immature [2, 3]

Text
Person et al TARGIT A letter Breast Cancer Res Treatment 2014.pdf - Version of Record
Restricted to Repository staff only

More information

Published date: June 2014
Organisations: Faculty of Health Sciences

Identifiers

Local EPrints ID: 367541
URI: http://eprints.soton.ac.uk/id/eprint/367541
ISSN: 0167-6806
PURE UUID: 9b0be248-5e76-414b-aab9-215fe2bc52d6

Catalogue record

Date deposited: 01 Aug 2014 16:36
Last modified: 14 Mar 2024 17:32

Export record

Altmetrics

Contributors

Author: Orit Kaidar-Person
Author: Philip Poortmans
Author: Suzanne Klimberg
Author: Joanne Haviland
Author: Birgitte Offersen
Author: Riccardo Audisio
Author: John Yarnold

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×