MDR1 C3435T genetic polymorphism does not influence the response to antiretroviral therapy in drug-naive HIV-positive patients
MDR1 C3435T genetic polymorphism does not influence the response to antiretroviral therapy in drug-naive HIV-positive patients
P-glycoprotein, a membrane-localized protein transporter, codified by the MDR1 gene, influences the response to pharmacological treatments, including antiretroviral drugs. MDR1 polymorphism C3435T is correlated with the functionality of the protein. We investigated the influence of this polymorphism in the reconstitution of the peripheral CD4 T cell pool in 149 drug-naive HIV-positive patients starting highly active antiretroviral therapy. The MDR1 C3435Tpolymorphism did not influence response to therapy, suggesting no disadvantages for individuals with a different genotype.
1696-1698
Nasi, Milena
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Borghi, Vanni
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Pinti, Marcello
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Bellodi, Cristian
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Lugli, Enrico
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Maffei, Stefania
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Troiano, Leonarda
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Richeldi, Luca
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Mussini, Cristina
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Esposito, Roberto
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Cossarizza, Andrea
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25 July 2003
Nasi, Milena
bf0c9a5f-178d-481a-a488-f7f3c83224c3
Borghi, Vanni
3766098a-53b6-4b63-9e32-11eb5bf9bb6f
Pinti, Marcello
69f4441e-83de-4ab5-a6c6-cf8373a31939
Bellodi, Cristian
73529fd4-a45e-40c4-98ef-fab8a5875fb5
Lugli, Enrico
d6029ce4-8427-4900-aa0b-841c4eef8787
Maffei, Stefania
43f67a38-25c0-4bf9-93fa-dd0b806309d4
Troiano, Leonarda
0d5e6564-753b-4d6e-92bc-a4fdfad531cd
Richeldi, Luca
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Mussini, Cristina
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Esposito, Roberto
ddb47c2a-f9d3-491a-bf05-3448e0a899d3
Cossarizza, Andrea
b83c2470-fee5-4ae4-ac9a-c554846f4600
Nasi, Milena, Borghi, Vanni, Pinti, Marcello, Bellodi, Cristian, Lugli, Enrico, Maffei, Stefania, Troiano, Leonarda, Richeldi, Luca, Mussini, Cristina, Esposito, Roberto and Cossarizza, Andrea
(2003)
MDR1 C3435T genetic polymorphism does not influence the response to antiretroviral therapy in drug-naive HIV-positive patients.
AIDS, 17 (11), .
(PMID:12853754)
Abstract
P-glycoprotein, a membrane-localized protein transporter, codified by the MDR1 gene, influences the response to pharmacological treatments, including antiretroviral drugs. MDR1 polymorphism C3435T is correlated with the functionality of the protein. We investigated the influence of this polymorphism in the reconstitution of the peripheral CD4 T cell pool in 149 drug-naive HIV-positive patients starting highly active antiretroviral therapy. The MDR1 C3435Tpolymorphism did not influence response to therapy, suggesting no disadvantages for individuals with a different genotype.
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Published date: 25 July 2003
Organisations:
Clinical & Experimental Sciences
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Local EPrints ID: 368944
URI: http://eprints.soton.ac.uk/id/eprint/368944
PURE UUID: 5e517e1f-2d5b-4644-987a-01bbb5a0fd1f
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Date deposited: 02 Oct 2014 14:00
Last modified: 22 Jul 2022 19:08
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Contributors
Author:
Milena Nasi
Author:
Vanni Borghi
Author:
Marcello Pinti
Author:
Cristian Bellodi
Author:
Enrico Lugli
Author:
Stefania Maffei
Author:
Leonarda Troiano
Author:
Luca Richeldi
Author:
Cristina Mussini
Author:
Roberto Esposito
Author:
Andrea Cossarizza
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