The University of Southampton
University of Southampton Institutional Repository

Clinical trials of investigational agents for IPF: a review of a Cochrane report

Clinical trials of investigational agents for IPF: a review of a Cochrane report
Clinical trials of investigational agents for IPF: a review of a Cochrane report
The magnitude of treatment effect can be assessed by a number of methods. One reliable method of collectively analysing data from randomised clinical trials is that used in Cochrane reviews. These systematic reviews identify and analyse the available evidence using the reliable method of meta-analysis. These often combine data from studies to provide robust evaluations of overall treatment effects. In 2003, a review of data from studies of corticosteroid use in IPF patients found no evidence of a treatment effect. Similarly, very little evidence was found to support the use of immunomodulatory agents. A recent update of these Cochrane reviews failed to identify any new evidence supporting the use of corticosteroids in IPF. However, a review of non-steroid agents for the treatment of IPF identified data from 15 RCTs that was suitable for analysis. Two trials of interferon gamma-1b were pooled and analysed, but no treatment effect was observed in terms of survival. Meta-analysis of three Phase III studies of pirfenidone treatment in IPF patients suggested that progression-free survival was significantly increased by 30%, demonstrating a reduction in the decline of lung function in IPF patients. In addition, there are numerous ongoing trials investigating potential therapeutic agents which provides hope for IPF patients and their doctors.
1465-9921
S4
Richeldi, Luca
47177d9c-731a-49a1-9cc6-4ac8f6bbbf26
Richeldi, Luca
47177d9c-731a-49a1-9cc6-4ac8f6bbbf26

Richeldi, Luca (2013) Clinical trials of investigational agents for IPF: a review of a Cochrane report. Respiratory Research, 14, supplement 1, S4. (doi:10.1186/1465-9921-14-S1-S4). (PMID:23734867)

Record type: Article

Abstract

The magnitude of treatment effect can be assessed by a number of methods. One reliable method of collectively analysing data from randomised clinical trials is that used in Cochrane reviews. These systematic reviews identify and analyse the available evidence using the reliable method of meta-analysis. These often combine data from studies to provide robust evaluations of overall treatment effects. In 2003, a review of data from studies of corticosteroid use in IPF patients found no evidence of a treatment effect. Similarly, very little evidence was found to support the use of immunomodulatory agents. A recent update of these Cochrane reviews failed to identify any new evidence supporting the use of corticosteroids in IPF. However, a review of non-steroid agents for the treatment of IPF identified data from 15 RCTs that was suitable for analysis. Two trials of interferon gamma-1b were pooled and analysed, but no treatment effect was observed in terms of survival. Meta-analysis of three Phase III studies of pirfenidone treatment in IPF patients suggested that progression-free survival was significantly increased by 30%, demonstrating a reduction in the decline of lung function in IPF patients. In addition, there are numerous ongoing trials investigating potential therapeutic agents which provides hope for IPF patients and their doctors.

This record has no associated files available for download.

More information

Published date: 16 April 2013
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 369096
URI: http://eprints.soton.ac.uk/id/eprint/369096
ISSN: 1465-9921
PURE UUID: 6feb7ac5-ab4f-4ee9-a830-3d04662196d5

Catalogue record

Date deposited: 24 Sep 2014 12:39
Last modified: 14 Mar 2024 17:58

Export record

Altmetrics

Contributors

Author: Luca Richeldi

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×