B cells - masters of the immunoverse
B cells - masters of the immunoverse
The immune system involves the complex interplay between many different cell types. Over the last decade, T cells, dendritic cells (DC) and macrophages have all been implicated as the key regulator cells of the immunological response, linking innate and adaptive immunity. The forgotten cell in this discourse has been the B-cell. Long considered as simple antibody production units dictated to by T-cells, recent years have begun to shift this assumption. The discovery that numerous B-cell subsets exist, with specific regulatory functions capable of modulating T-cell and chronic inflammatory responses has revealed a hitherto unappreciated role of B-cells. In particular, these ideas have been developed in light of the surprisingly successful responses delivered in autoimmune settings following depletion of B-cells with the anti-CD20 antibody rituximab. Here we summarise the history of the humble B-cell and discuss some of the key recent findings that lead us to propose it as an important regulator of ongoing immune responses and as such, one of the masters of the immunoverse.
B-cells, immunotherapy, autoimmunity, antibody, rituximab
280-285
Vaughan, Andrew T.
bfb2ceab-a592-457e-89f9-00fcd1dddbdb
Roghanian, Ali
e2b032c2-60a0-4522-a3d8-56a768792f36
Cragg, Mark S.
ec97f80e-f3c8-49b7-a960-20dff648b78c
March 2011
Vaughan, Andrew T.
bfb2ceab-a592-457e-89f9-00fcd1dddbdb
Roghanian, Ali
e2b032c2-60a0-4522-a3d8-56a768792f36
Cragg, Mark S.
ec97f80e-f3c8-49b7-a960-20dff648b78c
Abstract
The immune system involves the complex interplay between many different cell types. Over the last decade, T cells, dendritic cells (DC) and macrophages have all been implicated as the key regulator cells of the immunological response, linking innate and adaptive immunity. The forgotten cell in this discourse has been the B-cell. Long considered as simple antibody production units dictated to by T-cells, recent years have begun to shift this assumption. The discovery that numerous B-cell subsets exist, with specific regulatory functions capable of modulating T-cell and chronic inflammatory responses has revealed a hitherto unappreciated role of B-cells. In particular, these ideas have been developed in light of the surprisingly successful responses delivered in autoimmune settings following depletion of B-cells with the anti-CD20 antibody rituximab. Here we summarise the history of the humble B-cell and discuss some of the key recent findings that lead us to propose it as an important regulator of ongoing immune responses and as such, one of the masters of the immunoverse.
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e-pub ahead of print date: 13 December 2010
Published date: March 2011
Keywords:
B-cells, immunotherapy, autoimmunity, antibody, rituximab
Organisations:
Cancer Sciences
Identifiers
Local EPrints ID: 369607
URI: http://eprints.soton.ac.uk/id/eprint/369607
ISSN: 1357-2725
PURE UUID: e1ad3ed6-9d8b-4620-b0cc-87f3308e3b29
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Date deposited: 02 Oct 2014 10:51
Last modified: 15 Mar 2024 03:34
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Author:
Andrew T. Vaughan
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