Human neutrophil elastase inhibitors in innate and adaptive immunity
Human neutrophil elastase inhibitors in innate and adaptive immunity
Recent evidence shows that human neutrophil elastase inhibitors can be synthesized locally at mucosal sites. In addition to efficiently targeting bacterial and host enzymes, they can be released in the interstitium and in the lumen of mucosa, where they have been shown to have antimicrobial activities, and to activate innate immune responses. This review will address more particularly the pleiotropic functions of low-molecular-mass neutrophil elastase inhibitors [SLPI (secretory leucocyte proteinase inhibitor) and elafin] and, more specifically, their role in the development of the adaptive immune response.
?1 proteinase inhibitor, elafin, elastase, secretory leucocyte proteinase inhibitor (SLPI)
279-282
Fitch, P.M.
b3eda5a9-9b03-413c-8539-8a53d0e8c872
Roghanian, A.
e2b032c2-60a0-4522-a3d8-56a768792f36
Howie, S.E.M.
502974b9-c3f4-4bb4-b21c-5e70f74c72e8
Sallenave, J.-M.
c7dc85a3-e9b5-4fee-9175-491f5b26542c
April 2006
Fitch, P.M.
b3eda5a9-9b03-413c-8539-8a53d0e8c872
Roghanian, A.
e2b032c2-60a0-4522-a3d8-56a768792f36
Howie, S.E.M.
502974b9-c3f4-4bb4-b21c-5e70f74c72e8
Sallenave, J.-M.
c7dc85a3-e9b5-4fee-9175-491f5b26542c
Fitch, P.M., Roghanian, A., Howie, S.E.M. and Sallenave, J.-M.
(2006)
Human neutrophil elastase inhibitors in innate and adaptive immunity.
Biochemical Society Transactions, 34, part 2, .
(doi:10.1042/BST20060279).
(PMID:16545094)
Abstract
Recent evidence shows that human neutrophil elastase inhibitors can be synthesized locally at mucosal sites. In addition to efficiently targeting bacterial and host enzymes, they can be released in the interstitium and in the lumen of mucosa, where they have been shown to have antimicrobial activities, and to activate innate immune responses. This review will address more particularly the pleiotropic functions of low-molecular-mass neutrophil elastase inhibitors [SLPI (secretory leucocyte proteinase inhibitor) and elafin] and, more specifically, their role in the development of the adaptive immune response.
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Published date: April 2006
Keywords:
?1 proteinase inhibitor, elafin, elastase, secretory leucocyte proteinase inhibitor (SLPI)
Organisations:
Cancer Sciences
Identifiers
Local EPrints ID: 369715
URI: http://eprints.soton.ac.uk/id/eprint/369715
ISSN: 0300-5127
PURE UUID: 4fbf9773-86ad-41fb-8dc0-b1d82812c28c
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Date deposited: 06 Oct 2014 10:57
Last modified: 15 Mar 2024 03:34
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Author:
P.M. Fitch
Author:
S.E.M. Howie
Author:
J.-M. Sallenave
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