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Modular ‘click’ sensors for zinc and their application in vivo

Modular ‘click’ sensors for zinc and their application in vivo
Modular ‘click’ sensors for zinc and their application in vivo
Although the central role that zinc plays in many biological processes and important disease states is now well-established, there remains a pressing need to develop an absolute understanding of the underlying biology of zinc trafficking in terms of its dynamic and quantitative processing in specific organelles. Here we describe the modular synthesis of zinc sensors using a ‘click’ approach and demonstrate the applicability of our new sensors in vivo using a zebrafish model.
1359-7345
6036-6038
Jobe, Kajally
ab190c46-b176-4fa8-8e22-56ff9c75a526
Brennan, Caroline H.
2ee87ad9-61e0-4f43-846c-091f81626a31
Motevalli, Majid
af7052f4-8d95-4b22-865e-0c08793ee24a
Goldup, Stephen M.
0a93eedd-98bb-42c1-a963-e2815665e937
Watkinson, Michael
7405d50a-0e9d-4b31-8e23-0a3198eb1abd
Jobe, Kajally
ab190c46-b176-4fa8-8e22-56ff9c75a526
Brennan, Caroline H.
2ee87ad9-61e0-4f43-846c-091f81626a31
Motevalli, Majid
af7052f4-8d95-4b22-865e-0c08793ee24a
Goldup, Stephen M.
0a93eedd-98bb-42c1-a963-e2815665e937
Watkinson, Michael
7405d50a-0e9d-4b31-8e23-0a3198eb1abd

Jobe, Kajally, Brennan, Caroline H., Motevalli, Majid, Goldup, Stephen M. and Watkinson, Michael (2011) Modular ‘click’ sensors for zinc and their application in vivo. Chemical Communications, 47 (21), 6036-6038. (doi:10.1039/c1cc11213a). (PMID:21528144)

Record type: Article

Abstract

Although the central role that zinc plays in many biological processes and important disease states is now well-established, there remains a pressing need to develop an absolute understanding of the underlying biology of zinc trafficking in terms of its dynamic and quantitative processing in specific organelles. Here we describe the modular synthesis of zinc sensors using a ‘click’ approach and demonstrate the applicability of our new sensors in vivo using a zebrafish model.

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More information

Published date: 28 April 2011
Organisations: Organic Chemistry: Synthesis, Catalysis and Flow

Identifiers

Local EPrints ID: 370656
URI: http://eprints.soton.ac.uk/id/eprint/370656
ISSN: 1359-7345
PURE UUID: 31a0e6b4-6467-4e0b-a990-2289cf772248
ORCID for Stephen M. Goldup: ORCID iD orcid.org/0000-0003-3781-0464

Catalogue record

Date deposited: 03 Nov 2014 13:24
Last modified: 14 Mar 2024 18:20

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Contributors

Author: Kajally Jobe
Author: Caroline H. Brennan
Author: Majid Motevalli
Author: Michael Watkinson

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