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The growth restriction intervention trial: long-term outcomes in a randomized trial of timing of delivery in fetal growth restriction

The growth restriction intervention trial: long-term outcomes in a randomized trial of timing of delivery in fetal growth restriction
The growth restriction intervention trial: long-term outcomes in a randomized trial of timing of delivery in fetal growth restriction
Objective:
The Growth Restriction Intervention Trial found little difference in overall mortality or 2-year outcomes associated with immediate or deferred delivery following signs of impaired fetal health in the presence of growth restriction when the obstetrician was unsure whether to deliver. Because early childhood assessments have limited predictive value, we reevaluated them.

Study design:
Children were tested with standardized school-based evaluations of cognition, language, motor performance, and behavior. Analysis and interpretation were Bayesian.

Results:
Of 376 babies, 302 (80%) had known outcome: either dead or evaluated at age 6-13 years. Numbers of children dead, or with severe disability: 21 (14%) immediate and 25 (17%) deferred groups. Among survivors, the mean (SD) cognition scores were 95 (15) and 96 (14); motor scores were 8·9 (7·0) and 8·7 (6·7); and parent-assessed behavior scores were 10·5 (7·1) and 10·5 (6·9), respectively, for the 2 groups.

Conclusion:
Clinically significant differences between immediate and deferred delivery were not found.
cognitive function, neuropsychology, pediatric, premature
0002-9378
34.e1-34.e9
Walker, Dawn-Marie
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Marlow, Neil
0c6bd3b0-464b-4f04-8dd3-72517da5cbd7
Upstone, Lisa
0090f4ba-1d64-4fdd-8bb6-a419f70d65da
Gross, Harriet
d2b7cb38-c890-4a91-b9b7-88e7ea02abf2
Hornbuckle, Janet
ac5f7c15-652e-4428-9ee2-7247fd09b220
Vail, Andy
cb6d4b6d-2528-4a35-8f41-d55e0e59b312
Wolke, Dieter
a8934769-73fd-40da-a780-bd334d098387
Thornton, Jim G.
ac3af3ba-9b2e-4291-98d5-3618a853123f
Walker, Dawn-Marie
5d4c78b7-4411-493e-8844-b64efc72a1e8
Marlow, Neil
0c6bd3b0-464b-4f04-8dd3-72517da5cbd7
Upstone, Lisa
0090f4ba-1d64-4fdd-8bb6-a419f70d65da
Gross, Harriet
d2b7cb38-c890-4a91-b9b7-88e7ea02abf2
Hornbuckle, Janet
ac5f7c15-652e-4428-9ee2-7247fd09b220
Vail, Andy
cb6d4b6d-2528-4a35-8f41-d55e0e59b312
Wolke, Dieter
a8934769-73fd-40da-a780-bd334d098387
Thornton, Jim G.
ac3af3ba-9b2e-4291-98d5-3618a853123f

Walker, Dawn-Marie, Marlow, Neil, Upstone, Lisa, Gross, Harriet, Hornbuckle, Janet, Vail, Andy, Wolke, Dieter and Thornton, Jim G. (2011) The growth restriction intervention trial: long-term outcomes in a randomized trial of timing of delivery in fetal growth restriction. American Journal of Obstetrics and Gynecology, 204 (1), 34.e1-34.e9. (doi:10.1016/j.ajog.2010.09.019). (PMID:21056403)

Record type: Article

Abstract

Objective:
The Growth Restriction Intervention Trial found little difference in overall mortality or 2-year outcomes associated with immediate or deferred delivery following signs of impaired fetal health in the presence of growth restriction when the obstetrician was unsure whether to deliver. Because early childhood assessments have limited predictive value, we reevaluated them.

Study design:
Children were tested with standardized school-based evaluations of cognition, language, motor performance, and behavior. Analysis and interpretation were Bayesian.

Results:
Of 376 babies, 302 (80%) had known outcome: either dead or evaluated at age 6-13 years. Numbers of children dead, or with severe disability: 21 (14%) immediate and 25 (17%) deferred groups. Among survivors, the mean (SD) cognition scores were 95 (15) and 96 (14); motor scores were 8·9 (7·0) and 8·7 (6·7); and parent-assessed behavior scores were 10·5 (7·1) and 10·5 (6·9), respectively, for the 2 groups.

Conclusion:
Clinically significant differences between immediate and deferred delivery were not found.

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More information

e-pub ahead of print date: November 2010
Published date: January 2011
Keywords: cognitive function, neuropsychology, pediatric, premature
Organisations: Faculty of Health Sciences

Identifiers

Local EPrints ID: 372884
URI: http://eprints.soton.ac.uk/id/eprint/372884
ISSN: 0002-9378
PURE UUID: f0f2a642-9dd4-481e-bd00-7344a189c7fa
ORCID for Dawn-Marie Walker: ORCID iD orcid.org/0000-0003-2135-1363

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Date deposited: 22 Dec 2014 10:29
Last modified: 15 Mar 2024 03:51

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Contributors

Author: Dawn-Marie Walker ORCID iD
Author: Neil Marlow
Author: Lisa Upstone
Author: Harriet Gross
Author: Janet Hornbuckle
Author: Andy Vail
Author: Dieter Wolke
Author: Jim G. Thornton

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