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Effects of hypoxia on anabolic and catabolic gene expression and DNA methylation in OA chondrocytes

Effects of hypoxia on anabolic and catabolic gene expression and DNA methylation in OA chondrocytes
Effects of hypoxia on anabolic and catabolic gene expression and DNA methylation in OA chondrocytes
These findings demonstrate a role for hypoxia in the regulation of anabolic and catabolic gene expression and the influence of changes in DNA methylation. These results further support the role of epigenetics in OA and, critically, highlight the complex relationship between the physiological environment of cartilaginous cells and the osteoarthritic process with implications for therapeutic intervention and our understanding of OA pathophysiology.
hypoxia, cartilage, epigenetics, dna methylation, metabolism
431-[8pp]
Alvarez, Karl
d0a544ac-83fd-4ab8-bcab-4c3ff3480cd4
de Andrés, María C.
54e87e8a-1aa2-4907-a8a0-25d0c15e5e40
Takahashi, Atsushi
df2aaca3-d303-4f13-a444-0d15f5bb43b7
Oreffo, Richard O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Alvarez, Karl
d0a544ac-83fd-4ab8-bcab-4c3ff3480cd4
de Andrés, María C.
54e87e8a-1aa2-4907-a8a0-25d0c15e5e40
Takahashi, Atsushi
df2aaca3-d303-4f13-a444-0d15f5bb43b7
Oreffo, Richard O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778

Alvarez, Karl, de Andrés, María C., Takahashi, Atsushi and Oreffo, Richard O.C. (2014) Effects of hypoxia on anabolic and catabolic gene expression and DNA methylation in OA chondrocytes. BMC Musculoskeletal Disorders, 15 (1), 431-[8pp]. (doi:10.1186/1471-2474-15-431). (PMID:25510649)

Record type: Article

Abstract

These findings demonstrate a role for hypoxia in the regulation of anabolic and catabolic gene expression and the influence of changes in DNA methylation. These results further support the role of epigenetics in OA and, critically, highlight the complex relationship between the physiological environment of cartilaginous cells and the osteoarthritic process with implications for therapeutic intervention and our understanding of OA pathophysiology.

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Published date: 15 December 2014
Keywords: hypoxia, cartilage, epigenetics, dna methylation, metabolism
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 373157
URI: http://eprints.soton.ac.uk/id/eprint/373157
DOI: doi:10.1186/1471-2474-15-431
PURE UUID: fa3b86ec-9c23-4b4d-95af-3f710374698a
ORCID for Richard O.C. Oreffo: ORCID iD orcid.org/0000-0001-5995-6726

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Date deposited: 12 Jan 2015 10:12
Last modified: 15 Mar 2024 03:04

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Contributors

Author: Karl Alvarez
Author: María C. de Andrés
Author: Atsushi Takahashi
Author: Richard O.C. Oreffo ORCID iD

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