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Cancer incidence in people with residential exposure to a municipal waste incinerator: an ecological study in Modena (Italy), 1991-2005

Cancer incidence in people with residential exposure to a municipal waste incinerator: an ecological study in Modena (Italy), 1991-2005
Cancer incidence in people with residential exposure to a municipal waste incinerator: an ecological study in Modena (Italy), 1991-2005
We conducted a retrospective ecological study to assess cancer incidence during the period 1991-2005 in proximity of a municipal waste incinerator (MWI) in Modena (Italy). We identified three bands of increasing distance from the MWI, up to a radius of 5 km and used the residence as surrogate marker of the exposure. Residential history for Modena's population was reconstructed and residents were associated to the most appropriate census unit. Age-standardized incidence ratios (ASR) and standardized incidence ratios (SIR) were estimated for all cancers and selected sites. Variations in cancer incidence were investigated using space and space-time scan statistic. Deprivation index was taken into account as potential confounding factor. During the 15-year study period, 16,443 new cases of cancer were diagnosed among residents in Modena. The space-time clustering test identified three significant clusters but their shapes were not associable to the MWI exposition. The purely spatial analysis not showed statistically significant clusters. The SIR computed for all cancers and selected sites did not show any excess of risk in the area closest to the plant. Higher SIR for leukaemia was found in the second band from MWI (2-3.5 km) for females (SIR, age and DI adjusted: 1.35, 95%CI: 1.01-1.79) and for both sexes (SIR, age and DI adjusted: 1.28, 95%CI: 1.03-1.57), but not a spatial trend was observed, thus excluding a possible link with MWI. In conclusion, bearing in mind the intrinsic limits of the study, the results suggest that there is no detectable increase of cancer risk for people living in proximity to the Modena MWI.
0956-053X
1362-1370
Federico, Massimo
619243d1-85a2-4d50-8a7a-c1807595d7c5
Pirani, Monica
655b535b-5117-4a63-84e7-0588fbe0acc1
Rashid, Ivan
4a78fbb8-7202-406e-98c5-9ea8b6155419
Caranci, Nicola
b87ec696-d010-482e-ada7-5977034beaed
Cirilli, Claudia
b34f5fac-0449-4178-9120-e5290eb41246
Federico, Massimo
619243d1-85a2-4d50-8a7a-c1807595d7c5
Pirani, Monica
655b535b-5117-4a63-84e7-0588fbe0acc1
Rashid, Ivan
4a78fbb8-7202-406e-98c5-9ea8b6155419
Caranci, Nicola
b87ec696-d010-482e-ada7-5977034beaed
Cirilli, Claudia
b34f5fac-0449-4178-9120-e5290eb41246

Federico, Massimo, Pirani, Monica, Rashid, Ivan, Caranci, Nicola and Cirilli, Claudia (2010) Cancer incidence in people with residential exposure to a municipal waste incinerator: an ecological study in Modena (Italy), 1991-2005. Waste Management, 30 (7), 1362-1370. (doi:10.1016/j.wasman.2009.06.032). (PMID:19744847)

Record type: Article

Abstract

We conducted a retrospective ecological study to assess cancer incidence during the period 1991-2005 in proximity of a municipal waste incinerator (MWI) in Modena (Italy). We identified three bands of increasing distance from the MWI, up to a radius of 5 km and used the residence as surrogate marker of the exposure. Residential history for Modena's population was reconstructed and residents were associated to the most appropriate census unit. Age-standardized incidence ratios (ASR) and standardized incidence ratios (SIR) were estimated for all cancers and selected sites. Variations in cancer incidence were investigated using space and space-time scan statistic. Deprivation index was taken into account as potential confounding factor. During the 15-year study period, 16,443 new cases of cancer were diagnosed among residents in Modena. The space-time clustering test identified three significant clusters but their shapes were not associable to the MWI exposition. The purely spatial analysis not showed statistically significant clusters. The SIR computed for all cancers and selected sites did not show any excess of risk in the area closest to the plant. Higher SIR for leukaemia was found in the second band from MWI (2-3.5 km) for females (SIR, age and DI adjusted: 1.35, 95%CI: 1.01-1.79) and for both sexes (SIR, age and DI adjusted: 1.28, 95%CI: 1.03-1.57), but not a spatial trend was observed, thus excluding a possible link with MWI. In conclusion, bearing in mind the intrinsic limits of the study, the results suggest that there is no detectable increase of cancer risk for people living in proximity to the Modena MWI.

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e-pub ahead of print date: September 2009
Published date: July 2010
Organisations: Statistical Sciences Research Institute

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Local EPrints ID: 373192
URI: http://eprints.soton.ac.uk/id/eprint/373192
ISSN: 0956-053X
PURE UUID: 3c7af59e-4073-4ade-9b2c-cb25b4dea79a

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Date deposited: 12 Jan 2015 11:48
Last modified: 14 Mar 2024 18:49

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Contributors

Author: Massimo Federico
Author: Monica Pirani
Author: Ivan Rashid
Author: Nicola Caranci
Author: Claudia Cirilli

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