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Dietary intake, FTO genetic variants and adiposity: a combined analysis of over 16,000 children and adolescents

Dietary intake, FTO genetic variants and adiposity: a combined analysis of over 16,000 children and adolescents
Dietary intake, FTO genetic variants and adiposity: a combined analysis of over 16,000 children and adolescents
The FTO gene harbors variation with the strongest effect on adiposity and obesity risk. Previous data support a role for FTO variation in influencing food intake. We conducted a combined analysis of 16,094 boys and girls aged 1-18 years from 14 studies to examine: 1) the association between the FTO rs9939609 variant (or a proxy) and total energy and macronutrient intake; and 2) the interaction between the FTO variant and dietary intake on BMI. We found that the BMI-increasing allele (minor allele) of FTO variant was associated with increased total energy intake (effect per allele=14.3[5.9, 22.7] kcal/day, P=6.5×10(-4)) but not with protein, carbohydrate or fat intake. We also found that protein intake modified the association between the FTO variant and BMI (interactive effect per allele=0.08[0.03, 0.12]SDs, P for interaction=7.2×10(-4)): the association between FTO genotype and BMI was much stronger in individuals with high protein intake (effect per allele=0.10[0.07, 0.13]SDs, P=8.2×10(-10)) than in those with low intake (effect per allele=0.04[0.01, 0.07]SDs, P=0.02). Our results suggest that the FTO variant that confers a predisposition to higher BMI is associated with higher total energy intake and that lower dietary protein intake attenuates the association between FTO genotype and adiposity in children and adolescents.
0012-1797
2467-2476
Qi, Qibin
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Downer, Mary K.
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Kilpeläinen, Tuomas O.
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Taal, H. Rob
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Barton, Sheila J.
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Ntalla, Ioanna
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Standl, Marie
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Boraska, Vesna
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Huikari, Ville
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Kiefte-de Jong, Jessica C.
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Körner, Antje
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Lakka, Timo A.
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Liu, Gaifen
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Okuda, Masayuki
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Scheuermann, Kathrin
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Mossavar-Rahmani, Yasmin
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Jaddoe, Vincent W. V.
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Melén, Erik
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Pitsiladis, Yannis
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Snieder, Harold
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Heinrich, Joachim
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Timpson, Nicholas J.
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Wang, Tao
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Yuji, Hinoda
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Zeggini, Eleftheria
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Dedoussis, George V.
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Kaplan, Robert C.
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Wylie-Rosett, Judith
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Loos, Ruth J.F.
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Hu, Frank B.
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Qi, Lu
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Qi, Qibin
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Downer, Mary K.
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Kilpeläinen, Tuomas O.
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Taal, H. Rob
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Barton, Sheila J.
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Ntalla, Ioanna
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Standl, Marie
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Boraska, Vesna
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Huikari, Ville
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Kiefte-de Jong, Jessica C.
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Körner, Antje
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Lakka, Timo A.
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Liu, Gaifen
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Magnusson, Jessica
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Okuda, Masayuki
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Raitakari, Olli
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Richmond, Rebecca
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Scheuermann, Kathrin
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Jaddoe, Vincent W. V.
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Laitinen, Jaana
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Lindi, Virpi
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Melén, Erik
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Pitsiladis, Yannis
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Pitkänen, Niina
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Snieder, Harold
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Heinrich, Joachim
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Timpson, Nicholas J.
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Wang, Tao
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Yuji, Hinoda
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Zeggini, Eleftheria
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Dedoussis, George V.
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Kaplan, Robert C.
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Wylie-Rosett, Judith
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Loos, Ruth J.F.
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Hu, Frank B.
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Qi, Lu
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Qi, Qibin, Downer, Mary K., Kilpeläinen, Tuomas O., Taal, H. Rob, Barton, Sheila J., Ntalla, Ioanna, Standl, Marie, Boraska, Vesna, Huikari, Ville, Kiefte-de Jong, Jessica C., Körner, Antje, Lakka, Timo A., Liu, Gaifen, Magnusson, Jessica, Okuda, Masayuki, Raitakari, Olli, Richmond, Rebecca, Scott, Robert A., Bailey, Mark E. S., Scheuermann, Kathrin, Holloway, John W., Inskip, Hazel, Isasi, Carmen R., Mossavar-Rahmani, Yasmin, Jaddoe, Vincent W. V., Laitinen, Jaana, Lindi, Virpi, Melén, Erik, Pitsiladis, Yannis, Pitkänen, Niina, Snieder, Harold, Heinrich, Joachim, Timpson, Nicholas J., Wang, Tao, Yuji, Hinoda, Zeggini, Eleftheria, Dedoussis, George V., Kaplan, Robert C., Wylie-Rosett, Judith, Loos, Ruth J.F., Hu, Frank B. and Qi, Lu (2015) Dietary intake, FTO genetic variants and adiposity: a combined analysis of over 16,000 children and adolescents. Diabetes, 67 (7), 2467-2476. (doi:10.2337/db14-1629). (PMID:25720386)

Record type: Article

Abstract

The FTO gene harbors variation with the strongest effect on adiposity and obesity risk. Previous data support a role for FTO variation in influencing food intake. We conducted a combined analysis of 16,094 boys and girls aged 1-18 years from 14 studies to examine: 1) the association between the FTO rs9939609 variant (or a proxy) and total energy and macronutrient intake; and 2) the interaction between the FTO variant and dietary intake on BMI. We found that the BMI-increasing allele (minor allele) of FTO variant was associated with increased total energy intake (effect per allele=14.3[5.9, 22.7] kcal/day, P=6.5×10(-4)) but not with protein, carbohydrate or fat intake. We also found that protein intake modified the association between the FTO variant and BMI (interactive effect per allele=0.08[0.03, 0.12]SDs, P for interaction=7.2×10(-4)): the association between FTO genotype and BMI was much stronger in individuals with high protein intake (effect per allele=0.10[0.07, 0.13]SDs, P=8.2×10(-10)) than in those with low intake (effect per allele=0.04[0.01, 0.07]SDs, P=0.02). Our results suggest that the FTO variant that confers a predisposition to higher BMI is associated with higher total energy intake and that lower dietary protein intake attenuates the association between FTO genotype and adiposity in children and adolescents.

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More information

Accepted/In Press date: 26 February 2015
Published date: July 2015
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 375446
URI: http://eprints.soton.ac.uk/id/eprint/375446
ISSN: 0012-1797
PURE UUID: e83567c9-2345-4d1e-bfda-cc3faabbb669
ORCID for Sheila J. Barton: ORCID iD orcid.org/0000-0003-4963-4242
ORCID for John W. Holloway: ORCID iD orcid.org/0000-0001-9998-0464
ORCID for Hazel Inskip: ORCID iD orcid.org/0000-0001-8897-1749

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Date deposited: 26 Mar 2015 12:41
Last modified: 15 Mar 2024 03:10

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Contributors

Author: Qibin Qi
Author: Mary K. Downer
Author: Tuomas O. Kilpeläinen
Author: H. Rob Taal
Author: Ioanna Ntalla
Author: Marie Standl
Author: Vesna Boraska
Author: Ville Huikari
Author: Jessica C. Kiefte-de Jong
Author: Antje Körner
Author: Timo A. Lakka
Author: Gaifen Liu
Author: Jessica Magnusson
Author: Masayuki Okuda
Author: Olli Raitakari
Author: Rebecca Richmond
Author: Robert A. Scott
Author: Mark E. S. Bailey
Author: Kathrin Scheuermann
Author: Hazel Inskip ORCID iD
Author: Carmen R. Isasi
Author: Yasmin Mossavar-Rahmani
Author: Vincent W. V. Jaddoe
Author: Jaana Laitinen
Author: Virpi Lindi
Author: Erik Melén
Author: Yannis Pitsiladis
Author: Niina Pitkänen
Author: Harold Snieder
Author: Joachim Heinrich
Author: Nicholas J. Timpson
Author: Tao Wang
Author: Hinoda Yuji
Author: Eleftheria Zeggini
Author: George V. Dedoussis
Author: Robert C. Kaplan
Author: Judith Wylie-Rosett
Author: Ruth J.F. Loos
Author: Frank B. Hu
Author: Lu Qi

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