Role of aldehyde dehydrogenase in hypoxic vasodilator effects of nitrite in rats and humans
Role of aldehyde dehydrogenase in hypoxic vasodilator effects of nitrite in rats and humans
In human and rat vascular tissue in vitro, hypoxic nitrite-mediated vasodilatation involves ALDH2. In patients with heart failure in vivo the role of this enzyme in nitrite bioactivation is at most modest, suggesting the involvement of other more important mechanisms.
3341-3352
Arif, Sayqa
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Borgognone, Alessandra
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Lin, Erica Lai-Sze
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O'Sullivan, Aine G.
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Sharma, Vishal
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Drury, Nigel E.
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Menon, Ashvini
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Nightingale, Peter
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Mascaro, Jorge
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Bonser, Robert S.
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Horowitz, John D.
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Feelisch, Martin
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Frenneaux, Michael P.
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Madhani, Melanie
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Arif, Sayqa
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Borgognone, Alessandra
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Lin, Erica Lai-Sze
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O'Sullivan, Aine G.
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Sharma, Vishal
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Drury, Nigel E.
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Menon, Ashvini
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Nightingale, Peter
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Mascaro, Jorge
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Bonser, Robert S.
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Horowitz, John D.
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Feelisch, Martin
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Frenneaux, Michael P.
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Madhani, Melanie
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Arif, Sayqa, Borgognone, Alessandra, Lin, Erica Lai-Sze, O'Sullivan, Aine G., Sharma, Vishal, Drury, Nigel E., Menon, Ashvini, Nightingale, Peter, Mascaro, Jorge, Bonser, Robert S., Horowitz, John D., Feelisch, Martin, Frenneaux, Michael P. and Madhani, Melanie
(2015)
Role of aldehyde dehydrogenase in hypoxic vasodilator effects of nitrite in rats and humans.
British Journal of Pharmacology, 172, .
(doi:10.1111/bph.13122).
(PMID:25754766)
Abstract
In human and rat vascular tissue in vitro, hypoxic nitrite-mediated vasodilatation involves ALDH2. In patients with heart failure in vivo the role of this enzyme in nitrite bioactivation is at most modest, suggesting the involvement of other more important mechanisms.
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2014_Arif_et_al-2015-British_Journal_of_Pharmacology.pdf
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Accepted/In Press date: 9 February 2015
e-pub ahead of print date: 5 March 2015
Organisations:
Clinical & Experimental Sciences
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Local EPrints ID: 375464
URI: http://eprints.soton.ac.uk/id/eprint/375464
ISSN: 0007-1188
PURE UUID: befbb85f-abbc-42c8-a4c1-5bd5ac57a74d
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Date deposited: 27 Mar 2015 12:21
Last modified: 15 Mar 2024 03:42
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Contributors
Author:
Sayqa Arif
Author:
Alessandra Borgognone
Author:
Erica Lai-Sze Lin
Author:
Aine G. O'Sullivan
Author:
Vishal Sharma
Author:
Nigel E. Drury
Author:
Ashvini Menon
Author:
Peter Nightingale
Author:
Jorge Mascaro
Author:
Robert S. Bonser
Author:
John D. Horowitz
Author:
Michael P. Frenneaux
Author:
Melanie Madhani
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