Do infants with gastroschisis may have a high incidence of non-IgE-mediated cow's milk protein allergy?
Do infants with gastroschisis may have a high incidence of non-IgE-mediated cow's milk protein allergy?
Background/purpose
To determine the frequency and characteristics of suspected cow’s milk protein allergy (CMPA) in infants with gastroschisis and response to change in milk.
Methods
A retrospective cohort study of 111 consecutive infants with gastroschisis.
Results
64 episodes suggesting non-IgE-mediated CMPA occurred in 50 infants (45 %) at a median age of 44 days (9–186) and during the primary admission in 38 %. At the time of the episode the infant feed was breast milk (BM, n = 24), term formula (TF, n = 20) or extensively hydrolysed formula (EHF, n = 6). The feed was changed to EHF (34), amino acid formula (AAF) (14) or BM with maternal CMP-free diet (2). Partial or complete resolution of symptoms occurred in all. There was histological evidence of an allergic reaction to CMP in all four infants in whom tissue was available. Recurrent episodes occurred in 13/50 infants (26 %), 10 of whom were receiving EHF. There were no recurrent episodes in infants being fed with AAF.
Conclusion
Features suggesting non-IgE-mediated CMPA appear common in infants with gastroschisis.
gastroschisis, cow’s milk protein allergy, feeding
271-276
Burge, David
17a2f2a5-6228-4192-92df-838e0cccdbe5
Drewett, Melanie
017b4e4c-3143-40bf-bd6b-a36a8df51f3e
Hall, Nigel J.
6919e8af-3890-42c1-98a7-c110791957cf
28 January 2015
Burge, David
17a2f2a5-6228-4192-92df-838e0cccdbe5
Drewett, Melanie
017b4e4c-3143-40bf-bd6b-a36a8df51f3e
Hall, Nigel J.
6919e8af-3890-42c1-98a7-c110791957cf
Burge, David, Drewett, Melanie and Hall, Nigel J.
(2015)
Do infants with gastroschisis may have a high incidence of non-IgE-mediated cow's milk protein allergy?
Pediatric Surgery International, 31 (3), .
(doi:10.1007/s00383-015-3664-5).
(PMID:25627700)
Abstract
Background/purpose
To determine the frequency and characteristics of suspected cow’s milk protein allergy (CMPA) in infants with gastroschisis and response to change in milk.
Methods
A retrospective cohort study of 111 consecutive infants with gastroschisis.
Results
64 episodes suggesting non-IgE-mediated CMPA occurred in 50 infants (45 %) at a median age of 44 days (9–186) and during the primary admission in 38 %. At the time of the episode the infant feed was breast milk (BM, n = 24), term formula (TF, n = 20) or extensively hydrolysed formula (EHF, n = 6). The feed was changed to EHF (34), amino acid formula (AAF) (14) or BM with maternal CMP-free diet (2). Partial or complete resolution of symptoms occurred in all. There was histological evidence of an allergic reaction to CMP in all four infants in whom tissue was available. Recurrent episodes occurred in 13/50 infants (26 %), 10 of whom were receiving EHF. There were no recurrent episodes in infants being fed with AAF.
Conclusion
Features suggesting non-IgE-mediated CMPA appear common in infants with gastroschisis.
Text
Manuscript Burge rev 1.docx
- Accepted Manuscript
More information
Accepted/In Press date: 19 January 2015
Published date: 28 January 2015
Keywords:
gastroschisis, cow’s milk protein allergy, feeding
Organisations:
Human Development & Health
Identifiers
Local EPrints ID: 375572
URI: http://eprints.soton.ac.uk/id/eprint/375572
ISSN: 0179-0358
PURE UUID: ff9efc55-62fc-4fab-8a95-f6f751516e52
Catalogue record
Date deposited: 30 Mar 2015 11:19
Last modified: 15 Mar 2024 03:38
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Contributors
Author:
David Burge
Author:
Melanie Drewett
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