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Exposure to maternal gestational diabetes is associated with higher cardiovascular responses to stress in adolescent indians

Exposure to maternal gestational diabetes is associated with higher cardiovascular responses to stress in adolescent indians
Exposure to maternal gestational diabetes is associated with higher cardiovascular responses to stress in adolescent indians
Context:
Altered endocrinal and autonomic nervous system responses to stress may link impaired intra-uterine growth with later cardiovascular disease.

Objective:
To test the hypothesis that offspring of gestational diabetic mothers (OGDM) have high cortisol and cardiosympathetic responses during the Trier Social Stress Test for Children (TSST-C).

Design:
Adolescents from a birth cohort in India (n = 213; mean age, 13.5 y), including 26 OGDM, 22 offspring of diabetic fathers (ODF), and 165 offspring of nondiabetic parents (controls) completed 5 minutes each of public speaking and mental arithmetic tasks in front of two unfamiliar “evaluators” (TSST-C). Salivary cortisol concentrations were measured at baseline and at regular intervals after the TSST-C. Heart rate, blood pressure (BP), stroke volume, cardiac output, and total peripheral resistance were measured continuously at baseline, during the TSST-C, and for 10 minutes after the test using a finger cuff; the beat-to-beat values were averaged for these periods.

Results:
Cortisol and cardiosympathetic parameters increased from baseline during stress (P < .001). OGDM had greater systolic BP (mean difference, 5.6 mm Hg), cardiac output (0.5 L/min), and stroke volume (4.0 mL) increases and a lower total peripheral resistance rise (125 dyn · s/cm5) than controls during stress. ODF had greater systolic BP responses than controls (difference, 4.1 mm Hg); there was no difference in other cardiosympathetic parameters. Cortisol responses were similar in all three groups.

Conclusions:
Maternal diabetes during pregnancy is associated with higher cardiosympathetic stress responses in the offspring, which may contribute to their higher cardiovascular disease risk. Further research may confirm stress-response programming as a predictor of cardiovascular risk in OGDM.
0021-972X
986-993
Krishnaveni, G.V.
e9cc468a-8262-4dde-8eba-e047c68a3dce
Veena, S.R.
2acd1a9f-ce06-4cd2-bbdb-8f0057308e0e
Jones, A.
bcae84a4-4191-4a3e-b695-1b6e2b0681c7
Srinivasan, K.
a5367aa3-c40e-4c3c-825e-2d150a3e40c5
Osmond, Clive
2677bf85-494f-4a78-adf8-580e1b8acb81
Karat, S.C.
ed9c5413-3fa2-4d00-b283-d1936a907df4
Kurpad, A.V.
35ccfb0b-44b2-4dfc-969c-15160007f9c6
Fall, C.H.
7171a105-34f5-4131-89d7-1aa639893b18
Krishnaveni, G.V.
e9cc468a-8262-4dde-8eba-e047c68a3dce
Veena, S.R.
2acd1a9f-ce06-4cd2-bbdb-8f0057308e0e
Jones, A.
bcae84a4-4191-4a3e-b695-1b6e2b0681c7
Srinivasan, K.
a5367aa3-c40e-4c3c-825e-2d150a3e40c5
Osmond, Clive
2677bf85-494f-4a78-adf8-580e1b8acb81
Karat, S.C.
ed9c5413-3fa2-4d00-b283-d1936a907df4
Kurpad, A.V.
35ccfb0b-44b2-4dfc-969c-15160007f9c6
Fall, C.H.
7171a105-34f5-4131-89d7-1aa639893b18

Krishnaveni, G.V., Veena, S.R., Jones, A., Srinivasan, K., Osmond, Clive, Karat, S.C., Kurpad, A.V. and Fall, C.H. (2015) Exposure to maternal gestational diabetes is associated with higher cardiovascular responses to stress in adolescent indians. Journal of Clinical Endocrinology & Metabolism, 100 (3), 986-993. (doi:10.1210/jc.2014-3239). (PMID:25478935)

Record type: Article

Abstract

Context:
Altered endocrinal and autonomic nervous system responses to stress may link impaired intra-uterine growth with later cardiovascular disease.

Objective:
To test the hypothesis that offspring of gestational diabetic mothers (OGDM) have high cortisol and cardiosympathetic responses during the Trier Social Stress Test for Children (TSST-C).

Design:
Adolescents from a birth cohort in India (n = 213; mean age, 13.5 y), including 26 OGDM, 22 offspring of diabetic fathers (ODF), and 165 offspring of nondiabetic parents (controls) completed 5 minutes each of public speaking and mental arithmetic tasks in front of two unfamiliar “evaluators” (TSST-C). Salivary cortisol concentrations were measured at baseline and at regular intervals after the TSST-C. Heart rate, blood pressure (BP), stroke volume, cardiac output, and total peripheral resistance were measured continuously at baseline, during the TSST-C, and for 10 minutes after the test using a finger cuff; the beat-to-beat values were averaged for these periods.

Results:
Cortisol and cardiosympathetic parameters increased from baseline during stress (P < .001). OGDM had greater systolic BP (mean difference, 5.6 mm Hg), cardiac output (0.5 L/min), and stroke volume (4.0 mL) increases and a lower total peripheral resistance rise (125 dyn · s/cm5) than controls during stress. ODF had greater systolic BP responses than controls (difference, 4.1 mm Hg); there was no difference in other cardiosympathetic parameters. Cortisol responses were similar in all three groups.

Conclusions:
Maternal diabetes during pregnancy is associated with higher cardiosympathetic stress responses in the offspring, which may contribute to their higher cardiovascular disease risk. Further research may confirm stress-response programming as a predictor of cardiovascular risk in OGDM.

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More information

Accepted/In Press date: 1 December 2014
e-pub ahead of print date: 5 December 2014
Published date: March 2015
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 375584
URI: http://eprints.soton.ac.uk/id/eprint/375584
ISSN: 0021-972X
PURE UUID: 354eccd6-c0e4-4ec4-9e68-6a1468ce911d
ORCID for Clive Osmond: ORCID iD orcid.org/0000-0002-9054-4655
ORCID for C.H. Fall: ORCID iD orcid.org/0000-0003-4402-5552

Catalogue record

Date deposited: 02 Apr 2015 13:44
Last modified: 15 Mar 2024 02:50

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Contributors

Author: G.V. Krishnaveni
Author: S.R. Veena
Author: A. Jones
Author: K. Srinivasan
Author: Clive Osmond ORCID iD
Author: S.C. Karat
Author: A.V. Kurpad
Author: C.H. Fall ORCID iD

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