Randall-Selitto test: a new approach for the detection of neuropathic pain after spinal cord injury
Randall-Selitto test: a new approach for the detection of neuropathic pain after spinal cord injury
In this work we assess the usefulness of the Randall-Selitto test as a method to detect and quantify neuropathic pain responses in rats subjected to different spinal cord injuries. The mechanical nociceptive thresholds were significantly reduced during follow-up after spinal cord contusion or transection. Our results demonstrate that the Randall-Selitto test allows the detection of neuropathic pain both in forepaws and hindpaws, as well as in dorsal and plantar surfaces. Moreover, it does not require weight support capacity, so it can be used at early time points after the injury. This is the first time that this method has been used to describe the changes in nociceptive thresholds that take place after spinal cord injuries of different severities over time
898-904
Santos-Nogueira, Eva
70a3960e-d96c-4ef0-9847-79ae2c3236d5
Redondo Castro, Elena
a8fffa6a-be84-4d37-a4e8-19d4c4881f10
Mancuso, Renzo
05786562-a993-4e37-926e-3c1fcf50b36d
Navarro, Xavier
8854ebaa-d283-4d46-829e-c7c8f186585e
20 March 2012
Santos-Nogueira, Eva
70a3960e-d96c-4ef0-9847-79ae2c3236d5
Redondo Castro, Elena
a8fffa6a-be84-4d37-a4e8-19d4c4881f10
Mancuso, Renzo
05786562-a993-4e37-926e-3c1fcf50b36d
Navarro, Xavier
8854ebaa-d283-4d46-829e-c7c8f186585e
Santos-Nogueira, Eva, Redondo Castro, Elena, Mancuso, Renzo and Navarro, Xavier
(2012)
Randall-Selitto test: a new approach for the detection of neuropathic pain after spinal cord injury.
Journal of Neurotrauma, 29 (5), .
(doi:10.1089/neu.2010.1700).
(PMID:21682605)
Abstract
In this work we assess the usefulness of the Randall-Selitto test as a method to detect and quantify neuropathic pain responses in rats subjected to different spinal cord injuries. The mechanical nociceptive thresholds were significantly reduced during follow-up after spinal cord contusion or transection. Our results demonstrate that the Randall-Selitto test allows the detection of neuropathic pain both in forepaws and hindpaws, as well as in dorsal and plantar surfaces. Moreover, it does not require weight support capacity, so it can be used at early time points after the injury. This is the first time that this method has been used to describe the changes in nociceptive thresholds that take place after spinal cord injuries of different severities over time
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e-pub ahead of print date: 17 June 2011
Published date: 20 March 2012
Organisations:
Centre for Biological Sciences
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Local EPrints ID: 376114
URI: http://eprints.soton.ac.uk/id/eprint/376114
ISSN: 0897-7151
PURE UUID: a2373ee9-1a40-46c1-a237-18dc9f816f47
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Date deposited: 24 Apr 2015 09:21
Last modified: 14 Mar 2024 19:38
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Author:
Eva Santos-Nogueira
Author:
Elena Redondo Castro
Author:
Renzo Mancuso
Author:
Xavier Navarro
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