Lack of a synergistic effect of a non-viral ALS gene therapy based on BDNF and a TTC fusion molecule
Lack of a synergistic effect of a non-viral ALS gene therapy based on BDNF and a TTC fusion molecule
Significant improvements in behavioral and electrophysiological results, motoneuron survival and anti-apoptotic/survival-activated pathways were observed with BDNF-TTC treatment. However, no synergistic effect was found for this fusion molecule. Although BDNF in the fusion molecule is capable of activating autocrine and neuroprotective pathways, TTC treatment alone yielded similar neuroprotection. Therefore, an accurate study of the neuroprotective effects of TTC fusion molecules should be performed to obtain a better understanding of its effects
10
Calvo, Ana C.
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Moreno-Igoa, María
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Mancuso, Renzo
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Manzano, Raquel
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Oliván, Sara
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Muñoz, María J.
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Penas, Clara
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Zaragoza, Pilar
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Navarro, Xavier
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Osta, Rosario
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March 2011
Calvo, Ana C.
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Moreno-Igoa, María
335bc20a-91d8-4b07-aa94-881f7a8908b2
Mancuso, Renzo
05786562-a993-4e37-926e-3c1fcf50b36d
Manzano, Raquel
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Oliván, Sara
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Muñoz, María J.
3cc32a2d-b68a-4e9c-b7bd-f106fca029b4
Penas, Clara
650c6d8e-5990-4765-9a66-2b43fbfe46a1
Zaragoza, Pilar
c6176a36-77df-48e6-9a59-dad9c9a9932e
Navarro, Xavier
8854ebaa-d283-4d46-829e-c7c8f186585e
Osta, Rosario
64007891-e6c1-4242-ab1c-0c5e69276431
Calvo, Ana C., Moreno-Igoa, María, Mancuso, Renzo, Manzano, Raquel, Oliván, Sara, Muñoz, María J., Penas, Clara, Zaragoza, Pilar, Navarro, Xavier and Osta, Rosario
(2011)
Lack of a synergistic effect of a non-viral ALS gene therapy based on BDNF and a TTC fusion molecule.
Orphanet Journal of Rare Diseases, 6 (10), .
(doi:10.1186/1750-1172-6-10).
(PMID:21418619)
Abstract
Significant improvements in behavioral and electrophysiological results, motoneuron survival and anti-apoptotic/survival-activated pathways were observed with BDNF-TTC treatment. However, no synergistic effect was found for this fusion molecule. Although BDNF in the fusion molecule is capable of activating autocrine and neuroprotective pathways, TTC treatment alone yielded similar neuroprotection. Therefore, an accurate study of the neuroprotective effects of TTC fusion molecules should be performed to obtain a better understanding of its effects
Other
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Published date: March 2011
Organisations:
Centre for Biological Sciences
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Local EPrints ID: 376116
URI: http://eprints.soton.ac.uk/id/eprint/376116
ISSN: 1750-1172
PURE UUID: e7ae1f36-d805-4855-9892-37b5e9ee4c9d
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Date deposited: 24 Apr 2015 10:35
Last modified: 14 Mar 2024 19:38
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Author:
Ana C. Calvo
Author:
María Moreno-Igoa
Author:
Renzo Mancuso
Author:
Raquel Manzano
Author:
Sara Oliván
Author:
María J. Muñoz
Author:
Clara Penas
Author:
Pilar Zaragoza
Author:
Xavier Navarro
Author:
Rosario Osta
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