Activity intensity, assistive devices and joint replacement influence predicted remodelling in the proximal femur
Activity intensity, assistive devices and joint replacement influence predicted remodelling in the proximal femur
Bone morphology and density changes are commonly observed following joint replacement, and may contribute to the risks of implant loosening and periprosthetic fracture, and reduce the available bone stock for revision surgery. This study was presented in the “Bone and Cartilage Mechanobiology across the scales” WCCM symposium to review the development of remodelling prediction methods and to demonstrate simulation of adaptive bone remodelling around hip replacement femoral components, incorporating intrinsic (prosthesis) and extrinsic (activity and loading) factors.
An iterative bone remodelling process was applied to finite element models of a femur implanted with a cementless THR (total hip replacement) and a hip resurfacing implant. Previously developed for a cemented THR implant, this modified process enabled the influence of pre- to postoperative changes in patient activity and joint loading to be evaluated. A control algorithm used identical pre- and postoperative conditions, and the predicted extents and temporal trends of remodelling were measured by generating virtual x-rays and DXA scans.
The modified process improved qualitative and quantitative remodelling predictions for both the cementless THR and resurfacing implants, but demonstrated the sensitivity to DXA scan region definition and appropriate implant-bone position and sizing. Predicted remodelling in the intact femur in response to changed activity and loading demonstrated that in this simplified model, although the influence of the extrinsic effects were important, the mechanics of implantation were dominant. This study supports the application of predictive bone remodelling as one element in the range of physical and computational studies, which should be conducted in the pre-clinical evaluation of new prostheses.
predicted bone remodelling, total hip replacement, hip resurfacing, FE analysis
181-194
Dickinson, A.S.
10151972-c1b5-4f7d-bc12-6482b5870cad
8 March 2016
Dickinson, A.S.
10151972-c1b5-4f7d-bc12-6482b5870cad
Dickinson, A.S.
(2016)
Activity intensity, assistive devices and joint replacement influence predicted remodelling in the proximal femur.
Biomechanics and Modeling in Mechanobiology, 15 (1), .
(doi:10.1007/s10237-015-0678-9).
Abstract
Bone morphology and density changes are commonly observed following joint replacement, and may contribute to the risks of implant loosening and periprosthetic fracture, and reduce the available bone stock for revision surgery. This study was presented in the “Bone and Cartilage Mechanobiology across the scales” WCCM symposium to review the development of remodelling prediction methods and to demonstrate simulation of adaptive bone remodelling around hip replacement femoral components, incorporating intrinsic (prosthesis) and extrinsic (activity and loading) factors.
An iterative bone remodelling process was applied to finite element models of a femur implanted with a cementless THR (total hip replacement) and a hip resurfacing implant. Previously developed for a cemented THR implant, this modified process enabled the influence of pre- to postoperative changes in patient activity and joint loading to be evaluated. A control algorithm used identical pre- and postoperative conditions, and the predicted extents and temporal trends of remodelling were measured by generating virtual x-rays and DXA scans.
The modified process improved qualitative and quantitative remodelling predictions for both the cementless THR and resurfacing implants, but demonstrated the sensitivity to DXA scan region definition and appropriate implant-bone position and sizing. Predicted remodelling in the intact femur in response to changed activity and loading demonstrated that in this simplified model, although the influence of the extrinsic effects were important, the mechanics of implantation were dominant. This study supports the application of predictive bone remodelling as one element in the range of physical and computational studies, which should be conducted in the pre-clinical evaluation of new prostheses.
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Accepted/In Press date: 16 April 2015
e-pub ahead of print date: 17 July 2015
Published date: 8 March 2016
Keywords:
predicted bone remodelling, total hip replacement, hip resurfacing, FE analysis
Organisations:
Bioengineering Group
Identifiers
Local EPrints ID: 376173
URI: http://eprints.soton.ac.uk/id/eprint/376173
ISSN: 1617-7959
PURE UUID: c4bb5f22-6d01-4074-af2b-b6dbda71e896
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Date deposited: 28 Apr 2015 09:22
Last modified: 15 Mar 2024 03:27
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