Post-mortem analysis of neuroinflammatory changes in human Alzheimer's disease
Post-mortem analysis of neuroinflammatory changes in human Alzheimer's disease
Since the genome-wide association studies in Alzheimer’s disease have highlighted inflammation as a driver of the disease rather than a consequence of the ongoing neurodegeneration, numerous studies have been performed to identify specific immune profiles associated with healthy, ageing, or diseased brain. However, these studies have been performed mainly in in vitro or animal models, which recapitulate only some aspects of the pathophysiology of human Alzheimer’s disease. In this review, we discuss the availability of human post-mortem tissue through brain banks, the limitations associated with its use, the technical tools available, and the neuroimmune aspects to explore in order to validate in the human brain the experimental observations arising from animal models.
1-8
Gomez-Nicola, Diego
0680aa66-9dee-47cf-a8d3-e39c988f85b5
Boche, Delphine
bdcca10e-6302-4dd0-919f-67218f7e0d61
22 April 2015
Gomez-Nicola, Diego
0680aa66-9dee-47cf-a8d3-e39c988f85b5
Boche, Delphine
bdcca10e-6302-4dd0-919f-67218f7e0d61
Gomez-Nicola, Diego and Boche, Delphine
(2015)
Post-mortem analysis of neuroinflammatory changes in human Alzheimer's disease.
Alzheimer's Research & Therapy, 7 (42), .
(doi:10.1186/s13195-015-0126-1).
(PMID:25904988)
Abstract
Since the genome-wide association studies in Alzheimer’s disease have highlighted inflammation as a driver of the disease rather than a consequence of the ongoing neurodegeneration, numerous studies have been performed to identify specific immune profiles associated with healthy, ageing, or diseased brain. However, these studies have been performed mainly in in vitro or animal models, which recapitulate only some aspects of the pathophysiology of human Alzheimer’s disease. In this review, we discuss the availability of human post-mortem tissue through brain banks, the limitations associated with its use, the technical tools available, and the neuroimmune aspects to explore in order to validate in the human brain the experimental observations arising from animal models.
Text
s13195-015-0126-1.pdf
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Published date: 22 April 2015
Organisations:
Biomedicine, Clinical & Experimental Sciences
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Local EPrints ID: 376547
URI: http://eprints.soton.ac.uk/id/eprint/376547
ISSN: 1758-9193
PURE UUID: 621580e3-1916-4b88-be04-d7a793d60089
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Date deposited: 29 Apr 2015 11:54
Last modified: 15 Mar 2024 03:37
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