Metabotropic-mediated kainate receptor regulation of IsAHP and excitability in pyramidal cells

Melyan, Z., Wheal, H.V. and Lancaster, B. (2002) Metabotropic-mediated kainate receptor regulation of IsAHP and excitability in pyramidal cells. Neuron, 34, (1), 107-114. (doi:10.1016/S0896-6273(02)00624-4).


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Kainate receptors (KARs) on CA1 pyramidal cells make no detectable contribution to EPSCs. We report that these receptors have a metabotropic function, as shown previously for CA1 interneurons. Brief kainate exposure caused long-lasting inhibition of a postspike potassium current (IsAHP) in CA1 pyramidal cells. The pharmacological profile was independent of AMPA receptors or the GluR5 subunit, indicating a possible role for the GluR6 subunit. KAR inhibition of IsAHP did not require ionotropic action or network activity, but was blocked by the inhibitor of pertussis toxin-sensitive G proteins, N-ethylmaleimide (NEM), or the PKC inhibitor calphostin C. These data suggest how KARs, putatively containing GluR6, directly increase excitability of CA1 pyramidal cells and help explain the propensity for seizure activity following KAR activation.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1016/S0896-6273(02)00624-4
ISSNs: 0896-6273 (print)
Related URLs:
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Q Science > QH Natural history > QH301 Biology
Divisions : University Structure - Pre August 2011 > School of Biological Sciences
ePrint ID: 37720
Accepted Date and Publication Date:
Date Deposited: 25 May 2006
Last Modified: 31 Mar 2016 12:06

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