Can skin exposure to sunlight prevent liver inflammation?
Can skin exposure to sunlight prevent liver inflammation?
Liver inflammation contributes towards the pathology of non-alcoholic fatty liver disease (NAFLD). Here we discuss how skin exposure to sunlight may suppress liver inflammation and the severity of NAFLD. Following exposure to sunlight-derived ultraviolet radiation (UVR), the skin releases anti-inflammatory mediators such as vitamin D and nitric oxide. Animal modeling studies suggest that exposure to UVR can prevent the development of NAFLD. Association studies also support a negative link between circulating 25-hydroxyvitamin D and NAFLD incidence or severity. Clinical trials are in their infancy and are yet to demonstrate a clear beneficial effect of vitamin D supplementation. There are a number of potentially interdependent mechanisms whereby vitamin D could dampen liver inflammation, by inhibiting hepatocyte apoptosis and liver fibrosis, modulating the gut microbiome and through altered production and transport of bile acids. While there has been a focus on vitamin D, other mediators induced by sun exposure, such as nitric oxide may also play important roles in curtailing liver inflammation
3219-3239
Gorman, Shelley
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Black, Lucinda J.
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Feelisch, Martin
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Hart, Prue H.
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Weller, Richard
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5 May 2015
Gorman, Shelley
011f6b03-7b50-4c96-ab5e-9b0f6cc5c25d
Black, Lucinda J.
1ae17089-3bca-480d-a09c-ee1f9f349e95
Feelisch, Martin
8c1b9965-8614-4e85-b2c6-458a2e17eafd
Hart, Prue H.
30c350e2-ec01-48e9-8c5e-9ada39ab17ef
Weller, Richard
2f4ba01d-704b-421f-a486-9928b50793f9
Gorman, Shelley, Black, Lucinda J., Feelisch, Martin, Hart, Prue H. and Weller, Richard
(2015)
Can skin exposure to sunlight prevent liver inflammation?
Nutrients, 7 (5), .
(doi:10.3390/nu7053219).
(PMID:25951129)
Abstract
Liver inflammation contributes towards the pathology of non-alcoholic fatty liver disease (NAFLD). Here we discuss how skin exposure to sunlight may suppress liver inflammation and the severity of NAFLD. Following exposure to sunlight-derived ultraviolet radiation (UVR), the skin releases anti-inflammatory mediators such as vitamin D and nitric oxide. Animal modeling studies suggest that exposure to UVR can prevent the development of NAFLD. Association studies also support a negative link between circulating 25-hydroxyvitamin D and NAFLD incidence or severity. Clinical trials are in their infancy and are yet to demonstrate a clear beneficial effect of vitamin D supplementation. There are a number of potentially interdependent mechanisms whereby vitamin D could dampen liver inflammation, by inhibiting hepatocyte apoptosis and liver fibrosis, modulating the gut microbiome and through altered production and transport of bile acids. While there has been a focus on vitamin D, other mediators induced by sun exposure, such as nitric oxide may also play important roles in curtailing liver inflammation
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nutrients-07-03219.pdf
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Accepted/In Press date: 27 April 2015
Published date: 5 May 2015
Organisations:
Clinical & Experimental Sciences
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Local EPrints ID: 378734
URI: http://eprints.soton.ac.uk/id/eprint/378734
PURE UUID: aee4fd50-89e9-4fce-835f-d54d2d576609
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Date deposited: 09 Jul 2015 12:33
Last modified: 15 Mar 2024 03:42
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Author:
Shelley Gorman
Author:
Lucinda J. Black
Author:
Prue H. Hart
Author:
Richard Weller
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