The University of Southampton
University of Southampton Institutional Repository

Pressure induced deep tissue injury explained

Pressure induced deep tissue injury explained
Pressure induced deep tissue injury explained
The paper describes the current views on the cause of a sub-class of pressure ulcers known as pressure induced deep tissue injury (DTI). A multi-scale approach was adopted using model systems ranging from single cells in culture, tissue engineered muscle to animal studies with small animals. This has led to a clear understanding on two damage mechanisms associated with the development of DTI. Direct deformation results from high, but physiologically relevant, strains and is a process that leads to the first signs of cell damage within minutes. Ischaemic damage is caused by occlusion of blood vessels, but takes several hours to develop. The paper ends with some clinical consequences.
pressure ulcer, deep tissue injury, pressure sore, aetiology
0090-6964
297-305
Oomens, Cees W.J.
e8a85b85-3719-4909-9f82-4f03d8a43263
Bader, Daniel L.
9884d4f6-2607-4d48-bf0c-62bdcc0d1dbf
Loerakker, Sandra
77fe9fc8-bedb-4bd7-a7c1-864755dc0ec6
Baaijens, Frank
a52544ca-7ff4-4d14-a6ad-dc130612c917
Oomens, Cees W.J.
e8a85b85-3719-4909-9f82-4f03d8a43263
Bader, Daniel L.
9884d4f6-2607-4d48-bf0c-62bdcc0d1dbf
Loerakker, Sandra
77fe9fc8-bedb-4bd7-a7c1-864755dc0ec6
Baaijens, Frank
a52544ca-7ff4-4d14-a6ad-dc130612c917

Oomens, Cees W.J., Bader, Daniel L., Loerakker, Sandra and Baaijens, Frank (2015) Pressure induced deep tissue injury explained. Annals of Biomedical Engineering, 43 (2), 297-305. (doi:10.1007/s10439-014-1202-6). (PMID:25480479)

Record type: Article

Abstract

The paper describes the current views on the cause of a sub-class of pressure ulcers known as pressure induced deep tissue injury (DTI). A multi-scale approach was adopted using model systems ranging from single cells in culture, tissue engineered muscle to animal studies with small animals. This has led to a clear understanding on two damage mechanisms associated with the development of DTI. Direct deformation results from high, but physiologically relevant, strains and is a process that leads to the first signs of cell damage within minutes. Ischaemic damage is caused by occlusion of blood vessels, but takes several hours to develop. The paper ends with some clinical consequences.

Text
Pressure induced deep tissue injury explained oomens et al ABE 2014.pdf - Other
Restricted to Repository staff only
Request a copy

More information

Accepted/In Press date: 19 November 2014
e-pub ahead of print date: 6 December 2014
Published date: February 2015
Keywords: pressure ulcer, deep tissue injury, pressure sore, aetiology
Organisations: Faculty of Health Sciences

Identifiers

Local EPrints ID: 379933
URI: http://eprints.soton.ac.uk/id/eprint/379933
ISSN: 0090-6964
PURE UUID: 6390844c-fa78-4b8f-881b-3f90a26b26d2
ORCID for Daniel L. Bader: ORCID iD orcid.org/0000-0002-1208-3507

Catalogue record

Date deposited: 01 Sep 2015 09:19
Last modified: 14 Mar 2024 20:51

Export record

Altmetrics

Contributors

Author: Cees W.J. Oomens
Author: Daniel L. Bader ORCID iD
Author: Sandra Loerakker
Author: Frank Baaijens

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×