Inverse finite element modeling for characterization of local elastic properties in image-guided failure assessment of human trabecular bone

Zwahlen, Alexander, Christen, David, Ruffoni, Davide, Schneider, Philipp, Schmölz, Werner and Müller, Ralph (2015) Inverse finite element modeling for characterization of local elastic properties in image-guided failure assessment of human trabecular bone. Journal of Biomechanical Engineering, 137 (1), 1-9. (doi:10.1115/1.4028991). (PMID:25367315)

Abstract

The local interpretation of microfinite element (?FE) simulations plays a pivotal role for studying bone structure–function relationships such as failure processes and bone remodeling. In the past ?FE simulations have been successfully validated on the apparent level, however, at the tissue level validations are sparse and less promising. Furthermore, intratrabecular heterogeneity of the material properties has been shown by experimental studies. We proposed an inverse ?FE algorithm that iteratively changes the tissue level Young’s moduli such that the ?FE simulation matches the experimental strain measurements. The algorithm is setup as a feedback loop where the modulus is iteratively adapted until the simulated strain matches the experimental strain. The experimental strain of human trabecular bone specimens was calculated from time-lapsed images that were gained by combining mechanical testing and synchrotron radiation microcomputed tomography (SR?CT). The inverse ?FE algorithm was able to iterate the heterogeneous distribution of moduli such that the resulting ?FE simulations matched artificially generated and experimentally measured strains.

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Contributors

Author: Philipp Schneider

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