Platelet-derived growth factor-D and Rho GTPases regulate recruitment of cancer-associated fibroblasts in cholangiocarcinoma
Platelet-derived growth factor-D and Rho GTPases regulate recruitment of cancer-associated fibroblasts in cholangiocarcinoma
CCA cells express several mesenchymal markers, but do not transdifferentiate into CAFs. Instead, CCA cells recruit CAFs by secreting PDGF-D, which stimulates fibroblast migration through PDGFR? and Rho GTPase and JNK activation. Targeting tumor or stroma interactions with inhibitors of the PDGF-D pathway may offer a novel therapeutic approach
1042-1053
Cadamuro, Massimiliano
eee3861c-58b8-43a4-99d2-24f488b45eae
Nardo, Giorgia
4061e437-3c4f-442c-a21f-4a6b04dcd0e4
Indraccolo, Stefano
0d23f17a-6319-4215-99cc-1de6428de73c
Dall'olmo, Luigi
6115c805-1ac3-4308-a241-164db2726d38
Sambado, Luisa
b0171b6a-2017-4503-aee4-8607546e1b99
Moserle, Lidia
7d6213ce-4c45-4d83-8f41-e5f5067ba6de
Franceschet, Irene
79960b74-7697-4a00-9a62-0819b49723b4
Colledan, Michele
5dcf11ee-4a62-4d94-af58-900e5425fcdd
Massani, Marco
32fad209-0241-4168-8b07-06d17808a2b8
Stecca, Tommaso
196ca669-5540-4216-883d-ed9b32ee5ac8
Bassi, Nicolò
0b829168-b99e-4258-8cf6-9f7136cc9d58
Morton, Stuart
7545cf7d-15a6-43cc-9949-41ece1749fef
Spirli, Carlo
a71a179c-0648-4d86-aad3-978470660acd
Fiorotto, Romina
a3fb15a8-d882-4406-8d0e-6eeb95c98059
Fabris, Luca
7ab16fef-75b0-4131-a451-86fc97903b92
Strazzabosco, Mario
18e0c674-2971-4029-8c9f-7770f14ea564
September 2013
Cadamuro, Massimiliano
eee3861c-58b8-43a4-99d2-24f488b45eae
Nardo, Giorgia
4061e437-3c4f-442c-a21f-4a6b04dcd0e4
Indraccolo, Stefano
0d23f17a-6319-4215-99cc-1de6428de73c
Dall'olmo, Luigi
6115c805-1ac3-4308-a241-164db2726d38
Sambado, Luisa
b0171b6a-2017-4503-aee4-8607546e1b99
Moserle, Lidia
7d6213ce-4c45-4d83-8f41-e5f5067ba6de
Franceschet, Irene
79960b74-7697-4a00-9a62-0819b49723b4
Colledan, Michele
5dcf11ee-4a62-4d94-af58-900e5425fcdd
Massani, Marco
32fad209-0241-4168-8b07-06d17808a2b8
Stecca, Tommaso
196ca669-5540-4216-883d-ed9b32ee5ac8
Bassi, Nicolò
0b829168-b99e-4258-8cf6-9f7136cc9d58
Morton, Stuart
7545cf7d-15a6-43cc-9949-41ece1749fef
Spirli, Carlo
a71a179c-0648-4d86-aad3-978470660acd
Fiorotto, Romina
a3fb15a8-d882-4406-8d0e-6eeb95c98059
Fabris, Luca
7ab16fef-75b0-4131-a451-86fc97903b92
Strazzabosco, Mario
18e0c674-2971-4029-8c9f-7770f14ea564
Cadamuro, Massimiliano, Nardo, Giorgia, Indraccolo, Stefano, Dall'olmo, Luigi, Sambado, Luisa, Moserle, Lidia, Franceschet, Irene, Colledan, Michele, Massani, Marco, Stecca, Tommaso, Bassi, Nicolò, Morton, Stuart, Spirli, Carlo, Fiorotto, Romina, Fabris, Luca and Strazzabosco, Mario
(2013)
Platelet-derived growth factor-D and Rho GTPases regulate recruitment of cancer-associated fibroblasts in cholangiocarcinoma.
Hepatology, 58 (3), .
(doi:10.1002/hep.26384).
(PMID:23696149)
Abstract
CCA cells express several mesenchymal markers, but do not transdifferentiate into CAFs. Instead, CCA cells recruit CAFs by secreting PDGF-D, which stimulates fibroblast migration through PDGFR? and Rho GTPase and JNK activation. Targeting tumor or stroma interactions with inhibitors of the PDGF-D pathway may offer a novel therapeutic approach
This record has no associated files available for download.
More information
Published date: September 2013
Organisations:
Medical Education
Identifiers
Local EPrints ID: 382371
URI: http://eprints.soton.ac.uk/id/eprint/382371
ISSN: 0270-9139
PURE UUID: df72eba6-17f8-46b7-9c00-5ff1b0df5c6d
Catalogue record
Date deposited: 29 Oct 2015 11:56
Last modified: 15 Mar 2024 03:53
Export record
Altmetrics
Contributors
Author:
Massimiliano Cadamuro
Author:
Giorgia Nardo
Author:
Stefano Indraccolo
Author:
Luigi Dall'olmo
Author:
Luisa Sambado
Author:
Lidia Moserle
Author:
Irene Franceschet
Author:
Michele Colledan
Author:
Marco Massani
Author:
Tommaso Stecca
Author:
Nicolò Bassi
Author:
Carlo Spirli
Author:
Romina Fiorotto
Author:
Luca Fabris
Author:
Mario Strazzabosco
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
