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Sleep duration and growth outcomes across the first two years of life in the GUSTO study

Sleep duration and growth outcomes across the first two years of life in the GUSTO study
Sleep duration and growth outcomes across the first two years of life in the GUSTO study
Background and Aim: Short sleep duration is thought to be a factor contributing to increased body mass index (BMI) in both school-age children and adults. Our aim was to determine whether sleep duration associates with growth outcomes during the first two years of life.

Study design: Participants included 899 children enrolled in the Growing Up in Singapore Towards healthy Outcomes (GUSTO) birth cohort study. Anthropometric data (weight and body length) and parental reports of sleep duration were collected at 3, 6, 9, 12, 18, and 24 months of age. A mixed-model analysis was used to evaluate the longitudinal association of BMI and body length with sleep duration. In subgroup analyses, effects of ethnicity (Chinese, Indian, and Malay) and short sleep at three months of age (?12?h per day) were examined on subsequent growth measures.

Results: In the overall cohort, sleep duration was significantly associated with body length (??=?0.028, 95% confidence interval [CI] 0.002–0.053, p?=?0.033), but not BMI, after adjustment for potential confounding factors. Only in Malay children, shorter sleep was associated with a higher BMI (??=??0.042, 95% CI ?0.071 to ?0.012, p?=?0.005) and shorter body length (??=?0.079, 95% CI 0.030–0.128, p?=?0.002). In addition, shorter sleep was associated with a higher BMI and shorter body length in children who slept ?12?h per day at three months of age.

Conclusion: The association between sleep duration and growth outcomes begins in infancy. The small but significant relationship between sleep and growth anthropometric measures in early life might be amplified in later childhood.
sleep duration, children, growth, body mass index, body length, cohort study
1389-9457
1281-1286
Zhou, Yi
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Aris, Izzuddin M.
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Tan, Sara Shuhui
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Cai, Shirong
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Tint, Mya Thway
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Krishnaswamy, Gita
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Meaney, Michael J.
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Godfrey, Keith M.
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Kwek, Kenneth
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Gluckman, Peter D.
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Chong, Yap-Seng
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Yap, Fabian
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Lek, Ngee
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Gooley, Joshua J.
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Lee, Yung Seng
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Zhou, Yi
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Aris, Izzuddin M.
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Tan, Sara Shuhui
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Cai, Shirong
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Tint, Mya Thway
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Krishnaswamy, Gita
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Meaney, Michael J.
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Godfrey, Keith M.
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Kwek, Kenneth
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Gluckman, Peter D.
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Chong, Yap-Seng
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Yap, Fabian
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Lek, Ngee
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Gooley, Joshua J.
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Lee, Yung Seng
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Zhou, Yi, Aris, Izzuddin M., Tan, Sara Shuhui, Cai, Shirong, Tint, Mya Thway, Krishnaswamy, Gita, Meaney, Michael J., Godfrey, Keith M., Kwek, Kenneth, Gluckman, Peter D., Chong, Yap-Seng, Yap, Fabian, Lek, Ngee, Gooley, Joshua J. and Lee, Yung Seng (2015) Sleep duration and growth outcomes across the first two years of life in the GUSTO study. Sleep Medicine, 16 (10), 1281-1286. (doi:10.1016/j.sleep.2015.07.006). (PMID:26429758)

Record type: Article

Abstract

Background and Aim: Short sleep duration is thought to be a factor contributing to increased body mass index (BMI) in both school-age children and adults. Our aim was to determine whether sleep duration associates with growth outcomes during the first two years of life.

Study design: Participants included 899 children enrolled in the Growing Up in Singapore Towards healthy Outcomes (GUSTO) birth cohort study. Anthropometric data (weight and body length) and parental reports of sleep duration were collected at 3, 6, 9, 12, 18, and 24 months of age. A mixed-model analysis was used to evaluate the longitudinal association of BMI and body length with sleep duration. In subgroup analyses, effects of ethnicity (Chinese, Indian, and Malay) and short sleep at three months of age (?12?h per day) were examined on subsequent growth measures.

Results: In the overall cohort, sleep duration was significantly associated with body length (??=?0.028, 95% confidence interval [CI] 0.002–0.053, p?=?0.033), but not BMI, after adjustment for potential confounding factors. Only in Malay children, shorter sleep was associated with a higher BMI (??=??0.042, 95% CI ?0.071 to ?0.012, p?=?0.005) and shorter body length (??=?0.079, 95% CI 0.030–0.128, p?=?0.002). In addition, shorter sleep was associated with a higher BMI and shorter body length in children who slept ?12?h per day at three months of age.

Conclusion: The association between sleep duration and growth outcomes begins in infancy. The small but significant relationship between sleep and growth anthropometric measures in early life might be amplified in later childhood.

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Accepted/In Press date: 10 July 2015
e-pub ahead of print date: 17 July 2015
Published date: October 2015
Keywords: sleep duration, children, growth, body mass index, body length, cohort study
Organisations: NIHR Southampton Biomedical Research Centre

Identifiers

Local EPrints ID: 382771
URI: http://eprints.soton.ac.uk/id/eprint/382771
ISSN: 1389-9457
PURE UUID: f549c824-a209-45b4-9932-4bc5b9c96a40
ORCID for Keith M. Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

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Date deposited: 27 Oct 2015 14:16
Last modified: 15 Mar 2024 02:44

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Contributors

Author: Yi Zhou
Author: Izzuddin M. Aris
Author: Sara Shuhui Tan
Author: Shirong Cai
Author: Mya Thway Tint
Author: Gita Krishnaswamy
Author: Michael J. Meaney
Author: Kenneth Kwek
Author: Peter D. Gluckman
Author: Yap-Seng Chong
Author: Fabian Yap
Author: Ngee Lek
Author: Joshua J. Gooley
Author: Yung Seng Lee

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