Maternal high fat diet affects offspring's vitamin K-dependent proteins expression levels
Maternal high fat diet affects offspring's vitamin K-dependent proteins expression levels
Studies suggest bone growth & development and susceptibility to vascular disease in later life are influenced by maternal nutrition, during intrauterine and early postnatal life. There is evidence for a role of vitamin K-dependent proteins (VKDPs) including Osteocalcin, Matrix-gla protein, Periostin, and Gas6, in bone and vascular development. This study extends the analysis of VKDPs previously conducted in 6 week old offspring, into offspring of 30 weeks of age, to assess the longer term effects of a maternal and postnatal high fat (HF) diet on VKDP expression. Overall a HF maternal diet and offspring diet exacerbated the bone changes observed. Sex specific and tissue specific differences were observed in VKDP expression for both aorta and femoral tissues. In addition, significant correlations were observed between femoral OCN, Periostin Gas6, and Vkor expression levels and measures of femoral bone structure. Furthermore, MGP, OCN, Ggcx and Vkor expression levels correlated to mass and fat volume, in both sexes. In summary the current study has highlighted the importance of the long-term effects of maternal nutrition on offspring bone development and the correlation of VKDPs to bone structure.
1-19
Lanham, Stuart
28fdbbef-e3b6-4fdf-bd0f-4968eeb614d6
Cagampang, Felino R.
7cf57d52-4a65-4554-8306-ed65226bc50e
Oreffo, Richard O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
18 September 2015
Lanham, Stuart
28fdbbef-e3b6-4fdf-bd0f-4968eeb614d6
Cagampang, Felino R.
7cf57d52-4a65-4554-8306-ed65226bc50e
Oreffo, Richard O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Lanham, Stuart, Cagampang, Felino R. and Oreffo, Richard O.C.
(2015)
Maternal high fat diet affects offspring's vitamin K-dependent proteins expression levels.
PLoS ONE, 10 (9), .
(doi:10.1371/journal.pone.0138730).
(PMID:26381752)
Abstract
Studies suggest bone growth & development and susceptibility to vascular disease in later life are influenced by maternal nutrition, during intrauterine and early postnatal life. There is evidence for a role of vitamin K-dependent proteins (VKDPs) including Osteocalcin, Matrix-gla protein, Periostin, and Gas6, in bone and vascular development. This study extends the analysis of VKDPs previously conducted in 6 week old offspring, into offspring of 30 weeks of age, to assess the longer term effects of a maternal and postnatal high fat (HF) diet on VKDP expression. Overall a HF maternal diet and offspring diet exacerbated the bone changes observed. Sex specific and tissue specific differences were observed in VKDP expression for both aorta and femoral tissues. In addition, significant correlations were observed between femoral OCN, Periostin Gas6, and Vkor expression levels and measures of femoral bone structure. Furthermore, MGP, OCN, Ggcx and Vkor expression levels correlated to mass and fat volume, in both sexes. In summary the current study has highlighted the importance of the long-term effects of maternal nutrition on offspring bone development and the correlation of VKDPs to bone structure.
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Accepted/In Press date: 2 September 2015
Published date: 18 September 2015
Organisations:
Human Development & Health
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Local EPrints ID: 382860
URI: http://eprints.soton.ac.uk/id/eprint/382860
ISSN: 1932-6203
PURE UUID: 0e3660cd-e628-451c-baa9-977eaa9995bb
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Date deposited: 03 Nov 2015 15:39
Last modified: 15 Mar 2024 03:14
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Author:
Stuart Lanham
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