The roles of neuropeptides in Caenorhabditis elegans including their importance in the regulation of feeding and metabolism
The roles of neuropeptides in Caenorhabditis elegans including their importance in the regulation of feeding and metabolism
C. elegans has 302 neurons (in the adult hermaphrodite) and this simple nervous system harbours over 250 neuropeptides. Neuropeptides are a class of signalling molecule implicated in key physiological roles and thus confer a surprising level of complexity to signalling in this nematode. Indeed, it is probable that most, if not all, sensory, motor and interneurons, in C. elegans synthesise and release at least one neuropeptide but that many neurons synthesise an array of neuropeptides. In this review neuropeptides and their receptors with specific roles in feeding, metabolism, reproduction and locomotion are discussed. It is noted that the majority of C. elegans neuropeptides do not yet have defined roles and their cognate receptors have not yet been identified. Future studies will serve to provide further fundamental insight into how neuropeptide signalling can underpin animal behaviour
caenorhabditis elegans, neuropeptides, feeding, metabolism, locomotion, sensory responses
636-646
Holden-Dye, L.
8032bf60-5db6-40cb-b71c-ddda9d212c8e
Walker, R.
9368ac2d-f1e9-4bd9-a4b4-4a161c4aa140
June 2013
Holden-Dye, L.
8032bf60-5db6-40cb-b71c-ddda9d212c8e
Walker, R.
9368ac2d-f1e9-4bd9-a4b4-4a161c4aa140
Holden-Dye, L. and Walker, R.
(2013)
The roles of neuropeptides in Caenorhabditis elegans including their importance in the regulation of feeding and metabolism.
Proteins & Peptide Letter, 20 (6), .
(doi:10.2174/0929866511320060004).
(PMID:22630124)
Abstract
C. elegans has 302 neurons (in the adult hermaphrodite) and this simple nervous system harbours over 250 neuropeptides. Neuropeptides are a class of signalling molecule implicated in key physiological roles and thus confer a surprising level of complexity to signalling in this nematode. Indeed, it is probable that most, if not all, sensory, motor and interneurons, in C. elegans synthesise and release at least one neuropeptide but that many neurons synthesise an array of neuropeptides. In this review neuropeptides and their receptors with specific roles in feeding, metabolism, reproduction and locomotion are discussed. It is noted that the majority of C. elegans neuropeptides do not yet have defined roles and their cognate receptors have not yet been identified. Future studies will serve to provide further fundamental insight into how neuropeptide signalling can underpin animal behaviour
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Published date: June 2013
Keywords:
caenorhabditis elegans, neuropeptides, feeding, metabolism, locomotion, sensory responses
Organisations:
Centre for Biological Sciences
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Local EPrints ID: 383644
URI: http://eprints.soton.ac.uk/id/eprint/383644
ISSN: 0929-8665
PURE UUID: fbf5d6c2-c15f-4c18-9b2f-4f1f6d33c153
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Date deposited: 19 Nov 2015 11:43
Last modified: 15 Mar 2024 04:03
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