Postprandial effects of long-term niacin/laropiprant use on glucose and lipid metabolism and on cardiovascular risk in patients with polycystic ovary syndrome
Postprandial effects of long-term niacin/laropiprant use on glucose and lipid metabolism and on cardiovascular risk in patients with polycystic ovary syndrome
In PCOS, niacin/laropiprant had a significant negative impact on postprandial glucose and no improvement in postprandial hypertriglyceridaemia, with at least the former mediated through increased IR and reduced ?-cell function. This data may help explain why the improvement in fasting lipids has not translated into improved CV risk markers in PCOS
endothelial dysfunction, insulin resistance, niacin/laropiprant, polycystic ovary syndrome, triglycerides
545-552
Aye, M.M.
56d1288a-d5e4-4fdb-b29e-ece4d976f646
Kilpatrick, E.S.
48246b69-7bd3-4062-9b1f-6d68bfd82be4
Afolabi, P.
757e7f01-664c-493e-bc51-c6a2c933dc22
Wootton, S.A.
bf47ef35-0b33-4edb-a2b0-ceda5c475c0c
Rigby, A.S.
fb6c10e5-9f11-4ffe-9699-3f0505e63455
Coady, A.M.
2a781803-5113-4ef0-969d-38870132964e
Sandeman, D.D.
72922e30-8185-4745-8e50-dc77a5cf68ae
Atkin, S.L.
eece7cd7-8f18-4240-a788-d8a25f86e9e3
June 2014
Aye, M.M.
56d1288a-d5e4-4fdb-b29e-ece4d976f646
Kilpatrick, E.S.
48246b69-7bd3-4062-9b1f-6d68bfd82be4
Afolabi, P.
757e7f01-664c-493e-bc51-c6a2c933dc22
Wootton, S.A.
bf47ef35-0b33-4edb-a2b0-ceda5c475c0c
Rigby, A.S.
fb6c10e5-9f11-4ffe-9699-3f0505e63455
Coady, A.M.
2a781803-5113-4ef0-969d-38870132964e
Sandeman, D.D.
72922e30-8185-4745-8e50-dc77a5cf68ae
Atkin, S.L.
eece7cd7-8f18-4240-a788-d8a25f86e9e3
Aye, M.M., Kilpatrick, E.S., Afolabi, P., Wootton, S.A., Rigby, A.S., Coady, A.M., Sandeman, D.D. and Atkin, S.L.
(2014)
Postprandial effects of long-term niacin/laropiprant use on glucose and lipid metabolism and on cardiovascular risk in patients with polycystic ovary syndrome.
Diabetes, Obesity and Metabolism, 16 (6), .
(doi:10.1111/dom.12255).
(PMID:24401089)
Abstract
In PCOS, niacin/laropiprant had a significant negative impact on postprandial glucose and no improvement in postprandial hypertriglyceridaemia, with at least the former mediated through increased IR and reduced ?-cell function. This data may help explain why the improvement in fasting lipids has not translated into improved CV risk markers in PCOS
This record has no associated files available for download.
More information
Accepted/In Press date: 19 December 2013
e-pub ahead of print date: 9 February 2014
Published date: June 2014
Keywords:
endothelial dysfunction, insulin resistance, niacin/laropiprant, polycystic ovary syndrome, triglycerides
Organisations:
Human Development & Health
Identifiers
Local EPrints ID: 383785
URI: http://eprints.soton.ac.uk/id/eprint/383785
ISSN: 1462-8902
PURE UUID: 5d8f8e9a-f6c6-4899-b8f7-10c43519dcb9
Catalogue record
Date deposited: 20 Nov 2015 14:44
Last modified: 15 Mar 2024 02:51
Export record
Altmetrics
Contributors
Author:
M.M. Aye
Author:
E.S. Kilpatrick
Author:
P. Afolabi
Author:
A.S. Rigby
Author:
A.M. Coady
Author:
D.D. Sandeman
Author:
S.L. Atkin
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics