Fcγ receptors: genetic variation, function, and disease
Fcγ receptors: genetic variation, function, and disease
Fcγ receptors (FcγRs) are key immune receptors responsible for the effective control of both humoral and innate immunity and are central to maintaining the balance between generating appropriate responses to infection and preventing autoimmunity. When this balance is lost, pathology results in increased susceptibility to cancer, autoimmunity, and infection. In contrast, optimal FcγR engagement facilitates effective disease resolution and response to monoclonal antibody immunotherapy. The underlying genetics of the FcγR gene family are a central component of this careful balance. Complex in humans and generated through ancestral duplication events, here we review the evolution of the gene family in mammals, the potential importance of copy number, and functionally relevant single nucleotide polymorphisms, as well as discussing current approaches and limitations when exploring genetic variation in this region.
fc receptors, genetics, immunotherapy, antibodies
6-24
Hargreaves, Chantal
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Rose-Zerilli, Matthew
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Machado, L.
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Iriyama, C.
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Hollox, E.J.
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Cragg, Mark
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Strefford, Jon
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November 2015
Hargreaves, Chantal
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Rose-Zerilli, Matthew
08b3afa4-dbc2-4c0d-a852-2a9f33431199
Machado, L.
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Iriyama, C.
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Hollox, E.J.
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Cragg, Mark
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Strefford, Jon
3782b392-f080-42bf-bdca-8aa5d6ca532f
Hargreaves, Chantal, Rose-Zerilli, Matthew, Machado, L., Iriyama, C., Hollox, E.J., Cragg, Mark and Strefford, Jon
(2015)
Fcγ receptors: genetic variation, function, and disease.
[in special issue: Fc Receptors]
Immunological Reviews, 268 (1), .
(doi:10.1111/imr.12341).
(PMID:26497510)
Abstract
Fcγ receptors (FcγRs) are key immune receptors responsible for the effective control of both humoral and innate immunity and are central to maintaining the balance between generating appropriate responses to infection and preventing autoimmunity. When this balance is lost, pathology results in increased susceptibility to cancer, autoimmunity, and infection. In contrast, optimal FcγR engagement facilitates effective disease resolution and response to monoclonal antibody immunotherapy. The underlying genetics of the FcγR gene family are a central component of this careful balance. Complex in humans and generated through ancestral duplication events, here we review the evolution of the gene family in mammals, the potential importance of copy number, and functionally relevant single nucleotide polymorphisms, as well as discussing current approaches and limitations when exploring genetic variation in this region.
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2015 Hargreaves et al Immun Rev FCGR Genomics
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e-pub ahead of print date: 26 October 2015
Published date: November 2015
Keywords:
fc receptors, genetics, immunotherapy, antibodies
Organisations:
Cancer Sciences
Identifiers
Local EPrints ID: 384400
URI: http://eprints.soton.ac.uk/id/eprint/384400
ISSN: 0105-2896
PURE UUID: dd40d5f5-83df-45f3-9707-4ee9eae6e550
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Date deposited: 04 Jan 2016 10:26
Last modified: 15 Mar 2024 03:36
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Contributors
Author:
Chantal Hargreaves
Author:
L. Machado
Author:
C. Iriyama
Author:
E.J. Hollox
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