Computational modelling of placental amino acid transfer as an integrated system
Computational modelling of placental amino acid transfer as an integrated system
Placental amino acid transfer is essential for fetal development and its impairment is associated with poor fetal growth. Amino acid transfer is mediated by a broad array of specific plasma membrane transporters with overlapping substrate specificity. However, it is not fully understood how these different transporters work together to mediate net flux across the placenta. Therefore the aim of this study was to develop a new computational model to describe how human placental amino acid transfer functions as an integrated system. Amino acid transfer from mother to fetus requires transport across the two plasma membranes of the placental syncytiotrophoblast, each of which contains a distinct complement of transporter proteins. A compartmental modelling approach was combined with a carrier based modelling framework to represent the kinetics of the individual accumulative, exchange and facilitative classes of transporters on each plasma membrane. The model successfully captured the principal features of transplacental transfer. Modelling results clearly demonstrate how modulating transporter activity and conditions such as phenylketonuria, can increase the transfer of certain groups of amino acids, but that this comes at the cost of decreasing the transfer of others, which has implications for developing clinical treatment options in the placenta and other transporting epithelia.
The work using this model was published as: Pantichob et al, Computational modelling of placental amino acid transfer as an integrated system, BBA - Biomembranes 2016, accepted, http://dx.doi.org/10.1016/j.bbamem.2016.03.028
University of Southampton
Panitchob, Nuttanont
84152342-d60f-457b-9bb9-6d734c094a4e
Lewis, Rohan
caaeb97d-ea69-4f7b-8adb-5fa25e2d3502
Sengers, Bram
d6b771b1-4ede-48c5-9644-fa86503941aa
Panitchob, Nuttanont
84152342-d60f-457b-9bb9-6d734c094a4e
Lewis, Rohan
caaeb97d-ea69-4f7b-8adb-5fa25e2d3502
Sengers, Bram
d6b771b1-4ede-48c5-9644-fa86503941aa
Panitchob, Nuttanont, Lewis, Rohan and Sengers, Bram
(2016)
Computational modelling of placental amino acid transfer as an integrated system.
University of Southampton
doi:10.5258/SOTON/385034
[Dataset]
Abstract
Placental amino acid transfer is essential for fetal development and its impairment is associated with poor fetal growth. Amino acid transfer is mediated by a broad array of specific plasma membrane transporters with overlapping substrate specificity. However, it is not fully understood how these different transporters work together to mediate net flux across the placenta. Therefore the aim of this study was to develop a new computational model to describe how human placental amino acid transfer functions as an integrated system. Amino acid transfer from mother to fetus requires transport across the two plasma membranes of the placental syncytiotrophoblast, each of which contains a distinct complement of transporter proteins. A compartmental modelling approach was combined with a carrier based modelling framework to represent the kinetics of the individual accumulative, exchange and facilitative classes of transporters on each plasma membrane. The model successfully captured the principal features of transplacental transfer. Modelling results clearly demonstrate how modulating transporter activity and conditions such as phenylketonuria, can increase the transfer of certain groups of amino acids, but that this comes at the cost of decreasing the transfer of others, which has implications for developing clinical treatment options in the placenta and other transporting epithelia.
The work using this model was published as: Pantichob et al, Computational modelling of placental amino acid transfer as an integrated system, BBA - Biomembranes 2016, accepted, http://dx.doi.org/10.1016/j.bbamem.2016.03.028
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placentarun.zip
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Available under License Data: Open Data Commons Attribution License (Attribution).
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Published date: 2016
Additional Information:
The work using this model was published as: Pantichob et al, Computational modelling of placental amino acid transfer as an integrated system, BBA - Biomembranes 2016, accepted, http://dx.doi.org/10.1016/j.bbamem.2016.03.028
Organisations:
Faculty of Engineering and the Environment, Human Development & Health, Bioengineering Group
Projects:
Amino acid transport through the placenta: an experimental and modelling investigation
Funded by: UNSPECIFIED (BB/I011315/1)
21 November 2011 to 20 November 2014
Identifiers
Local EPrints ID: 385034
URI: http://eprints.soton.ac.uk/id/eprint/385034
PURE UUID: 31eec092-9471-4263-bc43-73a9a130bf39
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Date deposited: 14 Dec 2015 13:39
Last modified: 05 Nov 2023 02:41
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Creator:
Nuttanont Panitchob
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