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Perenosins: a new class of anion transporter with anti-cancer activity

Perenosins: a new class of anion transporter with anti-cancer activity
Perenosins: a new class of anion transporter with anti-cancer activity
A new class of anion transporter named ‘perenosins’ consisting of a pyrrole linked through an imine to either an indole, benzimidazole or indazole is reported. The indole containing members of the perenosin family function as effective transmembrane Cl?/NO3? antiporters and HCl cotransporters in a manner similar to the prodigiosenes. The compounds reduce the viability of MDA-MB-231 and MCF-7.
1477-0520
Van Rossom, Wim
4a3f4484-88e4-4bf8-aa7e-e36b646386b5
Asby, Daniel J.
cf0462d7-e923-45eb-b4ce-7c1673f544d5
Tavassoli, Ali
d561cf8f-2669-46b5-b6e1-2016c85d63b2
Gale, Philip A.
c840b7e9-6847-4843-91af-fa0f8563d943
Van Rossom, Wim
4a3f4484-88e4-4bf8-aa7e-e36b646386b5
Asby, Daniel J.
cf0462d7-e923-45eb-b4ce-7c1673f544d5
Tavassoli, Ali
d561cf8f-2669-46b5-b6e1-2016c85d63b2
Gale, Philip A.
c840b7e9-6847-4843-91af-fa0f8563d943

Van Rossom, Wim, Asby, Daniel J., Tavassoli, Ali and Gale, Philip A. (2016) Perenosins: a new class of anion transporter with anti-cancer activity. Organic & Biomolecular Chemistry. (doi:10.1039/C6OB00002A).

Record type: Article

Abstract

A new class of anion transporter named ‘perenosins’ consisting of a pyrrole linked through an imine to either an indole, benzimidazole or indazole is reported. The indole containing members of the perenosin family function as effective transmembrane Cl?/NO3? antiporters and HCl cotransporters in a manner similar to the prodigiosenes. The compounds reduce the viability of MDA-MB-231 and MCF-7.

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More information

Accepted/In Press date: 26 January 2016
e-pub ahead of print date: 1 February 2016
Organisations: Organic Chemistry: SCF

Identifiers

Local EPrints ID: 386512
URI: http://eprints.soton.ac.uk/id/eprint/386512
ISSN: 1477-0520
PURE UUID: 65f145f0-b00c-42e9-bfef-8b706c927f92
ORCID for Ali Tavassoli: ORCID iD orcid.org/0000-0002-7420-5063
ORCID for Philip A. Gale: ORCID iD orcid.org/0000-0001-9751-4910

Catalogue record

Date deposited: 01 Feb 2016 17:05
Last modified: 15 Mar 2024 03:26

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Contributors

Author: Wim Van Rossom
Author: Daniel J. Asby
Author: Ali Tavassoli ORCID iD
Author: Philip A. Gale ORCID iD

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