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Medical research council united kingdom refractory asthma stratification programme (RASP-UK)

Medical research council united kingdom refractory asthma stratification programme (RASP-UK)
Medical research council united kingdom refractory asthma stratification programme (RASP-UK)
The UK Refractory Asthma Stratification Programme (RASP-UK) will explore novel biomarker stratification strategies in severe asthma to improve clinical management and accelerate development of new therapies. Prior asthma mechanistic studies have not stratified on inflammatory phenotype and the understanding of pathophysiological mechanisms in asthma without Type 2 cytokine inflammation is limited. RASP-UK will objectively assess adherence to corticosteroids (CS) and examine a novel composite biomarker strategy to optimise CS dose; this will also address what proportion of patients with severe asthma have persistent symptoms without eosinophilic airways inflammation after progressive CS withdrawal. There will be interactive partnership with the pharmaceutical industry to facilitate access to stratified populations for novel therapeutic studies.
0040-6376
187-189
Heaney, L.G.
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Djukanovic, R.
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Woodcock, A.
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Walker, S.
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Matthews, J.G.
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Pavord, I.D.
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Bradding, P.
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Niven, R.
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Brightling, C.E.
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Chaudhuri, R.
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Arron, J.R.
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Choy, D.F.
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Cowan, D.
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Mansur, A.
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Menzies-Gow, A.
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Adcock, I.
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Chung, K.F.
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Corrigan, C.
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Coyle, P.
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Harrison, T.
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Johnston, S.
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Howarth, P.
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Lordan, J.
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Sabroe, I.
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Bigler, J.
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Smith, D.
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Catley, M.
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May, R.
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Pierre, L.
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Stevenson, C.
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Crater, G.
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Keane, F.
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Costello, R.W.
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Hudson, V.
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Supple, D.
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Hardman, T.
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Heaney, L.G.
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Djukanovic, R.
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Woodcock, A.
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Walker, S.
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Matthews, J.G.
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Pavord, I.D.
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Bradding, P.
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Niven, R.
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Brightling, C.E.
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Chaudhuri, R.
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Arron, J.R.
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Choy, D.F.
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Cowan, D.
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Mansur, A.
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Menzies-Gow, A.
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Adcock, I.
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Chung, K.F.
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Corrigan, C.
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Coyle, P.
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Harrison, T.
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Johnston, S.
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Howarth, P.
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Lordan, J.
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Sabroe, I.
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Bigler, J.
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Smith, D.
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Catley, M.
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May, R.
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Pierre, L.
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Stevenson, C.
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Crater, G.
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Keane, F.
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Costello, R.W.
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Hudson, V.
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Supple, D.
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Hardman, T.
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Heaney, L.G., Djukanovic, R., Woodcock, A., Walker, S., Matthews, J.G., Pavord, I.D., Bradding, P., Niven, R., Brightling, C.E., Chaudhuri, R., Arron, J.R., Choy, D.F., Cowan, D., Mansur, A., Menzies-Gow, A., Adcock, I., Chung, K.F., Corrigan, C., Coyle, P., Harrison, T., Johnston, S., Howarth, P., Lordan, J., Sabroe, I., Bigler, J., Smith, D., Catley, M., May, R., Pierre, L., Stevenson, C., Crater, G., Keane, F., Costello, R.W., Hudson, V., Supple, D. and Hardman, T. (2016) Medical research council united kingdom refractory asthma stratification programme (RASP-UK). Thorax, 71 (2), 187-189. (doi:10.1136/thoraxjnl-2015-207326). (PMID:26205878)

Record type: Article

Abstract

The UK Refractory Asthma Stratification Programme (RASP-UK) will explore novel biomarker stratification strategies in severe asthma to improve clinical management and accelerate development of new therapies. Prior asthma mechanistic studies have not stratified on inflammatory phenotype and the understanding of pathophysiological mechanisms in asthma without Type 2 cytokine inflammation is limited. RASP-UK will objectively assess adherence to corticosteroids (CS) and examine a novel composite biomarker strategy to optimise CS dose; this will also address what proportion of patients with severe asthma have persistent symptoms without eosinophilic airways inflammation after progressive CS withdrawal. There will be interactive partnership with the pharmaceutical industry to facilitate access to stratified populations for novel therapeutic studies.

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Accepted/In Press date: 22 June 2015
e-pub ahead of print date: 23 July 2015
Published date: February 2016
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 390633
URI: http://eprints.soton.ac.uk/id/eprint/390633
DOI: doi:10.1136/thoraxjnl-2015-207326
ISSN: 0040-6376
PURE UUID: 6b284629-f436-4f15-af4d-9ae7d82ffca1
ORCID for R. Djukanovic: ORCID iD orcid.org/0000-0001-6039-5612

Catalogue record

Date deposited: 06 Apr 2016 08:34
Last modified: 15 Mar 2024 02:36

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Contributors

Author: L.G. Heaney
Author: R. Djukanovic ORCID iD
Author: A. Woodcock
Author: S. Walker
Author: J.G. Matthews
Author: I.D. Pavord
Author: P. Bradding
Author: R. Niven
Author: C.E. Brightling
Author: R. Chaudhuri
Author: J.R. Arron
Author: D.F. Choy
Author: D. Cowan
Author: A. Mansur
Author: A. Menzies-Gow
Author: I. Adcock
Author: K.F. Chung
Author: C. Corrigan
Author: P. Coyle
Author: T. Harrison
Author: S. Johnston
Author: P. Howarth
Author: J. Lordan
Author: I. Sabroe
Author: J. Bigler
Author: D. Smith
Author: M. Catley
Author: R. May
Author: L. Pierre
Author: C. Stevenson
Author: G. Crater
Author: F. Keane
Author: R.W. Costello
Author: V. Hudson
Author: D. Supple
Author: T. Hardman

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