The University of Southampton
University of Southampton Institutional Repository

Pyrrolo [1,2,3-de] quinoxalines: unexpected products from 1,3-dipolar cycloaddition of dihydroimidazolium ylides

Pyrrolo [1,2,3-de] quinoxalines: unexpected products from 1,3-dipolar cycloaddition of dihydroimidazolium ylides
Pyrrolo [1,2,3-de] quinoxalines: unexpected products from 1,3-dipolar cycloaddition of dihydroimidazolium ylides
4,5-Dihydroimidazoles undergo an N-alkylation and 1,3-dipolar cycloaddition cascade with unsaturated ?-bromoketones, with subsequent eliminative ring-opening, recyclisation and tautomerisation to form unexpected hexahydropyrrolo[1,2,3-de]quinoxalines.
glycine binding-site, potent antagonists, pyrrolidines, pyrroloimidazoles, receptor
0040-4039
3951-3954
Jones, Raymond C. F.
50e973f9-3926-4126-bd59-4e2c0e9e8f98
Iley, James N.
b30fd482-e98a-440a-a13a-411d1c3bcdd3
Lory, Pedro M. J.
2212195a-ccc5-42c6-a276-8f65111a08f6
Coles, Simon C.
3116f58b-c30c-48cf-bdd5-397d1c1fecf8
Light, Mark E.
cf57314e-6856-491b-a8d2-2dffc452e161
Hursthouse, Michael B.
57a2ddf9-b1b3-4f38-bfe9-ef2f526388da
Jones, Raymond C. F.
50e973f9-3926-4126-bd59-4e2c0e9e8f98
Iley, James N.
b30fd482-e98a-440a-a13a-411d1c3bcdd3
Lory, Pedro M. J.
2212195a-ccc5-42c6-a276-8f65111a08f6
Coles, Simon C.
3116f58b-c30c-48cf-bdd5-397d1c1fecf8
Light, Mark E.
cf57314e-6856-491b-a8d2-2dffc452e161
Hursthouse, Michael B.
57a2ddf9-b1b3-4f38-bfe9-ef2f526388da

Jones, Raymond C. F., Iley, James N., Lory, Pedro M. J., Coles, Simon C., Light, Mark E. and Hursthouse, Michael B. (2001) Pyrrolo [1,2,3-de] quinoxalines: unexpected products from 1,3-dipolar cycloaddition of dihydroimidazolium ylides. Tetrahedron Letters, 42 (23), 3951-3954. (doi:10.1016/S0040-4039(01)00617-7).

Record type: Article

Abstract

4,5-Dihydroimidazoles undergo an N-alkylation and 1,3-dipolar cycloaddition cascade with unsaturated ?-bromoketones, with subsequent eliminative ring-opening, recyclisation and tautomerisation to form unexpected hexahydropyrrolo[1,2,3-de]quinoxalines.

This record has no associated files available for download.

More information

Published date: 2001
Keywords: glycine binding-site, potent antagonists, pyrrolidines, pyrroloimidazoles, receptor

Identifiers

Local EPrints ID: 39121
URI: http://eprints.soton.ac.uk/id/eprint/39121
ISSN: 0040-4039
PURE UUID: 947c2e64-51b5-4718-8014-608fe7809a27
ORCID for Simon C. Coles: ORCID iD orcid.org/0000-0001-8414-9272
ORCID for Mark E. Light: ORCID iD orcid.org/0000-0002-0585-0843

Catalogue record

Date deposited: 21 Jun 2006
Last modified: 16 Mar 2024 03:05

Export record

Altmetrics

Contributors

Author: Raymond C. F. Jones
Author: James N. Iley
Author: Pedro M. J. Lory
Author: Simon C. Coles ORCID iD
Author: Mark E. Light ORCID iD

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×