Contemporary biological factors in cochlear implantation and hearing preservation
Contemporary biological factors in cochlear implantation and hearing preservation
Residual hearing preservation is necessary for deaf patients to experience the full benefits of electro-acoustic stimulation cochlear implants. Hearing preservation is often considered a benchmark of successful atraumatic surgery and cochlear health preservation, making it an important goal of the procedure. The role of inflammatory status in hearing preservation has been empirically supported through the development of surgical protocols featuring corticosteroids. Its role is also inferred though investigations of inner-ear inflammatory responses, or studies of the inflammatory component in auditory pathologies. However, work directly investigating the effect of systemic inflammatory state on their audiological outcomes has never been attempted.
A multi-method research strategy consisting of: a murine immunohisto chemical pilot study, a meta-analysis of cochlear implant adverse events, a meta-analysis of factors related to hearing preservation, and a preliminary longitudinal observational clinical outcomes study was implemented. The results from the studies were incorporated into a conceptual framework of the relationship between multiple factors and their effect on outcomes in cochlear implantation. This body of work suggests that cochlear inflammatory state is a significant effector of hearing preservation. It introduces the concept of an individual's systemic inflammatory state having bearings on their clinical outcomes.
The consequences of this body of work include: i) suggested modifications to surgical protocols so as to maximise hearing preservation , ii) recommended routine monitoring of a patient's inflammatory state throughout their care pathway, iii) the importance of considering inflammatory state and the timing of a patient's surgery in order to allow for more stratified medicine, iv) a highlighted need for multi-centre collaborations in order to create a more exhaustive model of outcomes in hearing preservation surgery, and v) a need for deeper investigation of the pathophysiology of hearing loss for more guided research on deafness intervention.
Causon, Andrew
dde54d30-20ef-421e-bc35-7526afb2ff41
2016
Causon, Andrew
dde54d30-20ef-421e-bc35-7526afb2ff41
Verschuur, Carl
5e15ee1c-3a44-4dbe-ad43-ec3b50111e41
Causon, Andrew
(2016)
Contemporary biological factors in cochlear implantation and hearing preservation.
University of Southampton, Engineering and the Environment, Doctoral Thesis, 301pp.
Record type:
Thesis
(Doctoral)
Abstract
Residual hearing preservation is necessary for deaf patients to experience the full benefits of electro-acoustic stimulation cochlear implants. Hearing preservation is often considered a benchmark of successful atraumatic surgery and cochlear health preservation, making it an important goal of the procedure. The role of inflammatory status in hearing preservation has been empirically supported through the development of surgical protocols featuring corticosteroids. Its role is also inferred though investigations of inner-ear inflammatory responses, or studies of the inflammatory component in auditory pathologies. However, work directly investigating the effect of systemic inflammatory state on their audiological outcomes has never been attempted.
A multi-method research strategy consisting of: a murine immunohisto chemical pilot study, a meta-analysis of cochlear implant adverse events, a meta-analysis of factors related to hearing preservation, and a preliminary longitudinal observational clinical outcomes study was implemented. The results from the studies were incorporated into a conceptual framework of the relationship between multiple factors and their effect on outcomes in cochlear implantation. This body of work suggests that cochlear inflammatory state is a significant effector of hearing preservation. It introduces the concept of an individual's systemic inflammatory state having bearings on their clinical outcomes.
The consequences of this body of work include: i) suggested modifications to surgical protocols so as to maximise hearing preservation , ii) recommended routine monitoring of a patient's inflammatory state throughout their care pathway, iii) the importance of considering inflammatory state and the timing of a patient's surgery in order to allow for more stratified medicine, iv) a highlighted need for multi-centre collaborations in order to create a more exhaustive model of outcomes in hearing preservation surgery, and v) a need for deeper investigation of the pathophysiology of hearing loss for more guided research on deafness intervention.
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Final e-thesis for e-prints Causon, A 24495514.pdf
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Published date: 2016
Organisations:
University of Southampton, Inst. Sound & Vibration Research
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Local EPrints ID: 393704
URI: http://eprints.soton.ac.uk/id/eprint/393704
PURE UUID: de29ee79-cad5-43b8-9e2f-4170e6c535df
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Date deposited: 05 Jul 2016 14:17
Last modified: 15 Mar 2024 00:07
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Author:
Andrew Causon
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