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Diabetes and depression

Diabetes and depression
Diabetes and depression
Diabetes and depression occur together approximately twice as frequently as would be predicted by chance alone. Comorbid diabetes and depression are a major clinical challenge as the outcomes of both conditions are worsened by the other. Although the psychological burden of diabetes may contribute to depression, this explanation does not fully explain the relationship between these 2 conditions. Both conditions may be driven by shared underlying biological and behavioral mechanisms, such as hypothalamic-pituitary-adrenal axis activation, inflammation, sleep disturbance, inactive lifestyle, poor dietary habits, and environmental and cultural risk factors. Depression is frequently missed in people with diabetes despite effective screening tools being available. Both psychological interventions and antidepressants are effective in treating depressive symptoms in people with diabetes but have mixed effects on glycemic control. Clear care pathways involving a multidisciplinary team are needed to obtain optimal medical and psychiatric outcomes for people with comorbid diabetes and depression.
1534-4827
1-9
Holt, Richard I.G.
d54202e1-fcf6-4a17-a320-9f32d7024393
de Groot, Mary
012adc11-9bc9-4bf7-9090-d5b1b779ff66
Hill Golden, Sherita
f4938864-ef20-43f9-8736-3b4dce156e39
Holt, Richard I.G.
d54202e1-fcf6-4a17-a320-9f32d7024393
de Groot, Mary
012adc11-9bc9-4bf7-9090-d5b1b779ff66
Hill Golden, Sherita
f4938864-ef20-43f9-8736-3b4dce156e39

Holt, Richard I.G., de Groot, Mary and Hill Golden, Sherita (2014) Diabetes and depression. Current Diabetes Reports, 14 (491), 1-9. (doi:10.1007/s11892-014-0491-3). (PMID:24743941)

Record type: Article

Abstract

Diabetes and depression occur together approximately twice as frequently as would be predicted by chance alone. Comorbid diabetes and depression are a major clinical challenge as the outcomes of both conditions are worsened by the other. Although the psychological burden of diabetes may contribute to depression, this explanation does not fully explain the relationship between these 2 conditions. Both conditions may be driven by shared underlying biological and behavioral mechanisms, such as hypothalamic-pituitary-adrenal axis activation, inflammation, sleep disturbance, inactive lifestyle, poor dietary habits, and environmental and cultural risk factors. Depression is frequently missed in people with diabetes despite effective screening tools being available. Both psychological interventions and antidepressants are effective in treating depressive symptoms in people with diabetes but have mixed effects on glycemic control. Clear care pathways involving a multidisciplinary team are needed to obtain optimal medical and psychiatric outcomes for people with comorbid diabetes and depression.

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More information

e-pub ahead of print date: 18 April 2014
Published date: 14 June 2014
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 394657
URI: http://eprints.soton.ac.uk/id/eprint/394657
ISSN: 1534-4827
PURE UUID: 54928c00-5876-4df5-94ba-64d99d8046c6
ORCID for Richard I.G. Holt: ORCID iD orcid.org/0000-0001-8911-6744

Catalogue record

Date deposited: 23 May 2016 10:06
Last modified: 15 Mar 2024 03:08

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Contributors

Author: Mary de Groot
Author: Sherita Hill Golden

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