The University of Southampton
University of Southampton Institutional Repository

Embryos, DOHaD and David Barker

Embryos, DOHaD and David Barker
Embryos, DOHaD and David Barker
The early embryo and periconceptional period is a window during which environmental factors may cause permanent change in the pattern and characteristics of development leading to risk of adult onset disease. This has now been demonstrated across small and large animal models and also in the human. Most evidence of periconceptional ‘programming’ has emerged from maternal nutritional models but also other in vivo and in vitro conditions including assisted reproductive treatments, show consistent outcomes. This short review first reports on the range of environmental in vivo and in vitro periconceptional models and resulting long-term outcomes. Second, it uses the rodent maternal low protein diet model restricted to the preimplantation period and considers the stepwise maternal-embryonic dialogue that comprises the induction of programming. This dialogue leads to cellular and epigenetic responses by the embryo, mainly identified in the extra-embryonic cell lineages, and underpins an apparently permanent change in the growth trajectory during pregnancy and associates with increased cardiometabolic and behavioural disease in adulthood. We recognize the important advice of David Barker some years ago to investigate the sensitivity of the early embryo to developmental programming, an insight for which we are grateful.
377-383
Fleming, Thomas
2abf761a-e5a1-4fa7-a2c8-12e32d5d4c03
Velazquez, Miguel
6e3b2e05-6341-4087-90d6-e97cd6c15d25
Eckert, Judith
729bfa49-7053-458d-8e84-3e70e4d98e57
Fleming, Thomas
2abf761a-e5a1-4fa7-a2c8-12e32d5d4c03
Velazquez, Miguel
6e3b2e05-6341-4087-90d6-e97cd6c15d25
Eckert, Judith
729bfa49-7053-458d-8e84-3e70e4d98e57

Fleming, Thomas, Velazquez, Miguel and Eckert, Judith (2015) Embryos, DOHaD and David Barker. [in special issue: David Barker commemorative meeting, September 2014; Prenatal Exposures and Health Outcomes] Journal of Developmental Origins of Health and Disease, 6 (5), 377-383. (doi:10.1017/S2040174415001105). (PMID:25952250)

Record type: Article

Abstract

The early embryo and periconceptional period is a window during which environmental factors may cause permanent change in the pattern and characteristics of development leading to risk of adult onset disease. This has now been demonstrated across small and large animal models and also in the human. Most evidence of periconceptional ‘programming’ has emerged from maternal nutritional models but also other in vivo and in vitro conditions including assisted reproductive treatments, show consistent outcomes. This short review first reports on the range of environmental in vivo and in vitro periconceptional models and resulting long-term outcomes. Second, it uses the rodent maternal low protein diet model restricted to the preimplantation period and considers the stepwise maternal-embryonic dialogue that comprises the induction of programming. This dialogue leads to cellular and epigenetic responses by the embryo, mainly identified in the extra-embryonic cell lineages, and underpins an apparently permanent change in the growth trajectory during pregnancy and associates with increased cardiometabolic and behavioural disease in adulthood. We recognize the important advice of David Barker some years ago to investigate the sensitivity of the early embryo to developmental programming, an insight for which we are grateful.

Text
__filestore.soton.ac.uk_users_jje_mydocuments_Judith_papers_s1-ln1811889395844769-1939656818Hwf-762287073IdV126709282018118893PDF_HI0001.pdf - Accepted Manuscript
Restricted to Repository staff only
Request a copy

More information

Accepted/In Press date: 5 April 2015
e-pub ahead of print date: 8 May 2015
Published date: October 2015
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 395368
URI: http://eprints.soton.ac.uk/id/eprint/395368
PURE UUID: 5c417892-6e18-472e-87dc-f5ab9718bf7e

Catalogue record

Date deposited: 27 May 2016 11:31
Last modified: 15 Mar 2024 00:39

Export record

Altmetrics

Contributors

Author: Thomas Fleming
Author: Miguel Velazquez
Author: Judith Eckert

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×