Hemisphere asymmetry of response to pharmacologic treatment in an Alzheimer’s disease mouse model
Hemisphere asymmetry of response to pharmacologic treatment in an Alzheimer’s disease mouse model
The aim of this study was to examine hemisphere asymmetry of response to pharmacologic treatment in an Alzheimer’s disease mouse model using cilostazol as a chemical stimulus. Eight-month-old mice were assigned to vehicle or cilostazol treatment for three months and hemispheres were analyzed using quantitative proteomics. Bioinformatics interpretation showed that following treatment, aggregation of blood platelets significantly decreased in the right hemisphere whereas neurodegeneration significantly decreased and synaptic transmission increased in the left hemisphere only. Our study provides novel evidence on cerebral laterality of pharmacologic activity, with important implications in deciphering regional pharmacodynamic effects of existing drugs thus uncovering novel hemisphere-specific therapeutic targets.
333-338
Manousopoulou, Antigoni
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Saito, Satoshi
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Yamamoto, Yumi
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Al-Daghri, Nasser M.
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Ihara, Masafumi
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Carare, Roxana O.
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Garbis, Spiros D.
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15 March 2016
Manousopoulou, Antigoni
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Saito, Satoshi
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Yamamoto, Yumi
080c5181-118a-4bc4-a420-cb7c7b4f4da6
Al-Daghri, Nasser M.
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Ihara, Masafumi
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Carare, Roxana O.
0478c197-b0c1-4206-acae-54e88c8f21fa
Garbis, Spiros D.
7067fd19-50c9-4d42-9611-f370289470bd
Manousopoulou, Antigoni, Saito, Satoshi, Yamamoto, Yumi, Al-Daghri, Nasser M., Ihara, Masafumi, Carare, Roxana O. and Garbis, Spiros D.
(2016)
Hemisphere asymmetry of response to pharmacologic treatment in an Alzheimer’s disease mouse model.
Journal of Alzheimer's Disease, 51 (2), .
(doi:10.3233/JAD-151078).
(PMID:26836196)
Abstract
The aim of this study was to examine hemisphere asymmetry of response to pharmacologic treatment in an Alzheimer’s disease mouse model using cilostazol as a chemical stimulus. Eight-month-old mice were assigned to vehicle or cilostazol treatment for three months and hemispheres were analyzed using quantitative proteomics. Bioinformatics interpretation showed that following treatment, aggregation of blood platelets significantly decreased in the right hemisphere whereas neurodegeneration significantly decreased and synaptic transmission increased in the left hemisphere only. Our study provides novel evidence on cerebral laterality of pharmacologic activity, with important implications in deciphering regional pharmacodynamic effects of existing drugs thus uncovering novel hemisphere-specific therapeutic targets.
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Hemisphere Asymmetry of Response to Pharmacologic Treatment in an Alzheimer’s Disease Mouse Model.pdf
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Accepted/In Press date: 7 December 2015
Published date: 15 March 2016
Organisations:
Cancer Sciences
Identifiers
Local EPrints ID: 395372
URI: http://eprints.soton.ac.uk/id/eprint/395372
ISSN: 1387-2877
PURE UUID: 7cb2107e-4253-4a1c-a5cd-c8ba43438b19
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Date deposited: 27 May 2016 13:02
Last modified: 15 Mar 2024 03:01
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Contributors
Author:
Antigoni Manousopoulou
Author:
Satoshi Saito
Author:
Yumi Yamamoto
Author:
Nasser M. Al-Daghri
Author:
Masafumi Ihara
Author:
Spiros D. Garbis
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