Clinical proteomics and breast cancer
Clinical proteomics and breast cancer
Background: Breast cancer is a heterogeneous disease. Yet, many molecular players and mechanisms behind the complexity of its clinical behaviour remain unknown, and advances in biomedical research are expected to unravel novel molecular discoveries in breast and other cancers. Clinical proteomics is currently experiencing rapid advances in technology that promise new means to improve breast cancer early diagnosis, stratification, and treatment response.
Methods: We reviewed recent literature adopting clinical proteomics in breast cancer research.
Findings: This review highlights the principles, advantages, limitations, discoveries and future prospects of recent clinical proteomics discovery efforts in breast cancer research.
Conclusion: Numerous proteomic studies of breast cancer have been accomplished aiming to aid the development of personalised therapies, increase understanding of post treatment relapse, and help improve prediction of patient prognosis. This has led to the possible identification of profiles refining breast cancer subtypes and the discovery of novel biomarkers pointing towards diagnostic and prognostic potential.
271-278
Zeidan, Bashar A.
acd18415-22ee-43b8-a102-a36ea22dd0af
Townsend, Paul A.
a2680443-664e-46d0-b4dd-97456ba810db
Garbis, Spiros D.
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Copson, Ellen
a94cdbd6-f6e2-429d-a7c0-462c7da0e92b
Cutress, Ramsey I.
68ae4f86-e8cf-411f-a335-cdba51797406
October 2015
Zeidan, Bashar A.
acd18415-22ee-43b8-a102-a36ea22dd0af
Townsend, Paul A.
a2680443-664e-46d0-b4dd-97456ba810db
Garbis, Spiros D.
7067fd19-50c9-4d42-9611-f370289470bd
Copson, Ellen
a94cdbd6-f6e2-429d-a7c0-462c7da0e92b
Cutress, Ramsey I.
68ae4f86-e8cf-411f-a335-cdba51797406
Zeidan, Bashar A., Townsend, Paul A., Garbis, Spiros D., Copson, Ellen and Cutress, Ramsey I.
(2015)
Clinical proteomics and breast cancer.
The Surgeon, 13 (5), .
(doi:10.1016/j.surge.2014.12.003).
(PMID:25736469)
Abstract
Background: Breast cancer is a heterogeneous disease. Yet, many molecular players and mechanisms behind the complexity of its clinical behaviour remain unknown, and advances in biomedical research are expected to unravel novel molecular discoveries in breast and other cancers. Clinical proteomics is currently experiencing rapid advances in technology that promise new means to improve breast cancer early diagnosis, stratification, and treatment response.
Methods: We reviewed recent literature adopting clinical proteomics in breast cancer research.
Findings: This review highlights the principles, advantages, limitations, discoveries and future prospects of recent clinical proteomics discovery efforts in breast cancer research.
Conclusion: Numerous proteomic studies of breast cancer have been accomplished aiming to aid the development of personalised therapies, increase understanding of post treatment relapse, and help improve prediction of patient prognosis. This has led to the possible identification of profiles refining breast cancer subtypes and the discovery of novel biomarkers pointing towards diagnostic and prognostic potential.
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Accepted/In Press date: 24 December 2014
e-pub ahead of print date: 24 February 2015
Published date: October 2015
Organisations:
Cancer Sciences
Identifiers
Local EPrints ID: 395386
URI: http://eprints.soton.ac.uk/id/eprint/395386
ISSN: 1479-666X
PURE UUID: b7efce04-fae8-42b5-862f-0ed28e0f182d
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Date deposited: 27 May 2016 14:13
Last modified: 15 Mar 2024 00:39
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Contributors
Author:
Bashar A. Zeidan
Author:
Paul A. Townsend
Author:
Spiros D. Garbis
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