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Novel technologies and future perspectives of drug-eluting stent

Novel technologies and future perspectives of drug-eluting stent
Novel technologies and future perspectives of drug-eluting stent
As compared with bare metal stents (BMS), Drug-eluting stents (DES) have dramatically reduced the incidence of target lesion revascularization and neointimal formation. There are, however, potential toxic effects of DES upon arterial tissue. Previous pathological studies have indicated that durable polymers and the drug itself play critical role in delayed endothelialization, persistent inflammation, hypersensitivity, apoptosis, necrosis, and positive remodeling leading to adverse cardiovascular events. To address these issues, new generation DES, biodegradable polymers, polymer-free and fully bioabsorbable scaffolds are currently in evolution. This review summarized the clinical trials that have assessed the feasibility and efficacy of new generation DES. A number of pivotal trials have also demonstrated the non-inferiority of biodegradable polymer or polymer-free DES to durable polymer DES in terms of clinical outcomes and angiographic in-stent late loss, although long-term follow-up data remain sparse. Fully absorbable DES has also provided promising results in selected populations and requires sufficiently powered randomized studies to assess their safety and efficacy.
1-7
Wakabayashi, K.
25b3fe2c-4e62-40df-a018-3e0104737d1b
Pakala, R.
1fde788f-deb0-463c-b832-16e21b84edaf
Mahmoudi, M.
1dfae087-fe15-4e03-9f1a-510a4a84a6d5
Watanabe, T.
1c584711-f7b0-43e5-8ecc-e618aa689855
Mori, H.
fcac8133-6490-4ee8-9d83-5c7825a79959
Iso, Y.
e6217e2d-8bd3-49df-8011-76f228c958ad
Suzuki, H.
b031a39c-abef-4b64-a2a7-a87ccb0636d4
Wakabayashi, K.
25b3fe2c-4e62-40df-a018-3e0104737d1b
Pakala, R.
1fde788f-deb0-463c-b832-16e21b84edaf
Mahmoudi, M.
1dfae087-fe15-4e03-9f1a-510a4a84a6d5
Watanabe, T.
1c584711-f7b0-43e5-8ecc-e618aa689855
Mori, H.
fcac8133-6490-4ee8-9d83-5c7825a79959
Iso, Y.
e6217e2d-8bd3-49df-8011-76f228c958ad
Suzuki, H.
b031a39c-abef-4b64-a2a7-a87ccb0636d4

Wakabayashi, K., Pakala, R., Mahmoudi, M., Watanabe, T., Mori, H., Iso, Y. and Suzuki, H. (2012) Novel technologies and future perspectives of drug-eluting stent. Translational Medicine, S7 (2), 1-7. (doi:10.4172/2161-1025.S7-002).

Record type: Article

Abstract

As compared with bare metal stents (BMS), Drug-eluting stents (DES) have dramatically reduced the incidence of target lesion revascularization and neointimal formation. There are, however, potential toxic effects of DES upon arterial tissue. Previous pathological studies have indicated that durable polymers and the drug itself play critical role in delayed endothelialization, persistent inflammation, hypersensitivity, apoptosis, necrosis, and positive remodeling leading to adverse cardiovascular events. To address these issues, new generation DES, biodegradable polymers, polymer-free and fully bioabsorbable scaffolds are currently in evolution. This review summarized the clinical trials that have assessed the feasibility and efficacy of new generation DES. A number of pivotal trials have also demonstrated the non-inferiority of biodegradable polymer or polymer-free DES to durable polymer DES in terms of clinical outcomes and angiographic in-stent late loss, although long-term follow-up data remain sparse. Fully absorbable DES has also provided promising results in selected populations and requires sufficiently powered randomized studies to assess their safety and efficacy.

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More information

Accepted/In Press date: 12 March 2012
Published date: 14 March 2012
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 395483
URI: http://eprints.soton.ac.uk/id/eprint/395483
PURE UUID: e9146cbe-6a03-442e-b4c4-fe27f0d22bcf

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Date deposited: 14 Jul 2016 15:25
Last modified: 15 Mar 2024 00:41

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Contributors

Author: K. Wakabayashi
Author: R. Pakala
Author: M. Mahmoudi
Author: T. Watanabe
Author: H. Mori
Author: Y. Iso
Author: H. Suzuki

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