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Membrane protein structure, function, and dynamics: a perspective from experiments and theory

Membrane protein structure, function, and dynamics: a perspective from experiments and theory
Membrane protein structure, function, and dynamics: a perspective from experiments and theory
Membrane proteins mediate processes that are fundamental for the flourishing of biological cells. Membrane-embedded transporters move ions and larger solutes across membranes; receptors mediate communication between the cell and its environment and membrane-embedded enzymes catalyze chemical reactions. Understanding these mechanisms of action requires knowledge of how the proteins couple to their fluid, hydrated lipid membrane environment. We present here current studies in computational and experimental membrane protein biophysics, and show how they address outstanding challenges in understanding the complex environmental effects on the structure, function, and dynamics of membrane proteins.
0022-2631
611-640
Cournia, Zoe
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Allen, Toby W.
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Andricioaei, Ioan
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Antonny, Bruno
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Baum, Daniel
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Brannigan, Grace
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Buchete, Nicolae-Viorel
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Deckman, Jason T.
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Delemotte, Lucie
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del Val, Coral
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Friedman, Ran
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Gkeka, Paraskevi
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Hege, Hans-Christian
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Hénin, Jérôme
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Kasimova, Marina A.
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Kolocouris, Antonios
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Klein, Michael L.
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Khalid, Syma
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Lemieux, M. Joanne
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Lindow, Norbert
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Roy, Mahua
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Selent, Jana
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Tarek, Mounir
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Tofoleanu, Florentina
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Vanni, Stefano
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Urban, Sinisa
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Wales, David J.
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Smith, Jeremy C.
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Bondar, Ana-Nicoleta
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Cournia, Zoe
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Allen, Toby W.
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Andricioaei, Ioan
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Antonny, Bruno
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Baum, Daniel
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Brannigan, Grace
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Buchete, Nicolae-Viorel
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Deckman, Jason T.
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Delemotte, Lucie
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del Val, Coral
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Friedman, Ran
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Gkeka, Paraskevi
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Hege, Hans-Christian
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Hénin, Jérôme
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Kasimova, Marina A.
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Kolocouris, Antonios
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Klein, Michael L.
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Khalid, Syma
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Lemieux, M. Joanne
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Lindow, Norbert
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Roy, Mahua
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Selent, Jana
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Tarek, Mounir
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Tofoleanu, Florentina
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Vanni, Stefano
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Urban, Sinisa
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Wales, David J.
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Smith, Jeremy C.
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Bondar, Ana-Nicoleta
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Cournia, Zoe, Allen, Toby W., Andricioaei, Ioan, Antonny, Bruno, Baum, Daniel, Brannigan, Grace, Buchete, Nicolae-Viorel, Deckman, Jason T., Delemotte, Lucie, del Val, Coral, Friedman, Ran, Gkeka, Paraskevi, Hege, Hans-Christian, Hénin, Jérôme, Kasimova, Marina A., Kolocouris, Antonios, Klein, Michael L., Khalid, Syma, Lemieux, M. Joanne, Lindow, Norbert, Roy, Mahua, Selent, Jana, Tarek, Mounir, Tofoleanu, Florentina, Vanni, Stefano, Urban, Sinisa, Wales, David J., Smith, Jeremy C. and Bondar, Ana-Nicoleta (2015) Membrane protein structure, function, and dynamics: a perspective from experiments and theory. The Journal of Membrane Biology, 248 (4), 611-640. (doi:10.1007/s00232-015-9802-0). (PMID:26063070)

Record type: Article

Abstract

Membrane proteins mediate processes that are fundamental for the flourishing of biological cells. Membrane-embedded transporters move ions and larger solutes across membranes; receptors mediate communication between the cell and its environment and membrane-embedded enzymes catalyze chemical reactions. Understanding these mechanisms of action requires knowledge of how the proteins couple to their fluid, hydrated lipid membrane environment. We present here current studies in computational and experimental membrane protein biophysics, and show how they address outstanding challenges in understanding the complex environmental effects on the structure, function, and dynamics of membrane proteins.

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More information

e-pub ahead of print date: 11 June 2015
Published date: August 2015
Organisations: Computational Systems Chemistry

Identifiers

Local EPrints ID: 395512
URI: http://eprints.soton.ac.uk/id/eprint/395512
ISSN: 0022-2631
PURE UUID: f5f545f2-9de2-401c-83d9-d28f8eefc60f
ORCID for Syma Khalid: ORCID iD orcid.org/0000-0002-3694-5044

Catalogue record

Date deposited: 31 May 2016 14:37
Last modified: 15 Mar 2024 03:29

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Contributors

Author: Zoe Cournia
Author: Toby W. Allen
Author: Ioan Andricioaei
Author: Bruno Antonny
Author: Daniel Baum
Author: Grace Brannigan
Author: Nicolae-Viorel Buchete
Author: Jason T. Deckman
Author: Lucie Delemotte
Author: Coral del Val
Author: Ran Friedman
Author: Paraskevi Gkeka
Author: Hans-Christian Hege
Author: Jérôme Hénin
Author: Marina A. Kasimova
Author: Antonios Kolocouris
Author: Michael L. Klein
Author: Syma Khalid ORCID iD
Author: M. Joanne Lemieux
Author: Norbert Lindow
Author: Mahua Roy
Author: Jana Selent
Author: Mounir Tarek
Author: Florentina Tofoleanu
Author: Stefano Vanni
Author: Sinisa Urban
Author: David J. Wales
Author: Jeremy C. Smith
Author: Ana-Nicoleta Bondar

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