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The chromosome 9 ALS and FTD locus is probably derived from a single founder

The chromosome 9 ALS and FTD locus is probably derived from a single founder
The chromosome 9 ALS and FTD locus is probably derived from a single founder
We and others have recently reported an association between amyotrophic lateral sclerosis (ALS) and single nucleotide polymorphisms on chromosome 9p21 in several populations. Here we show that the associated haplotype is the same in all populations and that several families previously shown to have genetic linkage to this region also share this haplotype. The most parsimonious explanation of these data are that there is a single founder for this form of disease.
209.e3-209.e8
Mok, Kin
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Traynor, Bryan J.
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Schymick, Jennifer
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Tienari, Pentti J.
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Laaksovirta, Hannu
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Peuralinna, Terhi
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Myllykangas, Liisa
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Chiò, Adriano
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Shatunov, Aleksey
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Boeve, Bradley F.
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Boxer, Adam L.
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DeJesus-Hernandez, Mariely
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Mackenzie, Ian R.
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Waite, Adrian
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Williams, Nigel
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Morris, Huw R.
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Simón-Sánchez, Javier
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van Swieten, John C.
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Heutink, Peter
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Restagno, Gabriella
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Mora, Gabriele
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Morrison, Karen E.
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Shaw, Pamela J.
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Rollinson, Pamela Sara
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Al-Chalabi, Ammar
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Rademakers, Rosa
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Pickering-Brown, Stuart
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Orrell, Richard W.
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Nalls, Michael A.
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Hardy, John
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Mok, Kin
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Traynor, Bryan J.
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Schymick, Jennifer
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Tienari, Pentti J.
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Laaksovirta, Hannu
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Peuralinna, Terhi
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Myllykangas, Liisa
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Chiò, Adriano
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Shatunov, Aleksey
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Boeve, Bradley F.
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Boxer, Adam L.
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DeJesus-Hernandez, Mariely
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Mackenzie, Ian R.
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Waite, Adrian
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Williams, Nigel
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Morris, Huw R.
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Simón-Sánchez, Javier
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van Swieten, John C.
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Heutink, Peter
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Restagno, Gabriella
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Mora, Gabriele
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Morrison, Karen E.
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Shaw, Pamela J.
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Rollinson, Pamela Sara
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Al-Chalabi, Ammar
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Rademakers, Rosa
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Pickering-Brown, Stuart
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Orrell, Richard W.
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Nalls, Michael A.
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Hardy, John
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Mok, Kin, Traynor, Bryan J., Schymick, Jennifer, Tienari, Pentti J., Laaksovirta, Hannu, Peuralinna, Terhi, Myllykangas, Liisa, Chiò, Adriano, Shatunov, Aleksey, Boeve, Bradley F., Boxer, Adam L., DeJesus-Hernandez, Mariely, Mackenzie, Ian R., Waite, Adrian, Williams, Nigel, Morris, Huw R., Simón-Sánchez, Javier, van Swieten, John C., Heutink, Peter, Restagno, Gabriella, Mora, Gabriele, Morrison, Karen E., Shaw, Pamela J., Rollinson, Pamela Sara, Al-Chalabi, Ammar, Rademakers, Rosa, Pickering-Brown, Stuart, Orrell, Richard W., Nalls, Michael A. and Hardy, John (2012) The chromosome 9 ALS and FTD locus is probably derived from a single founder. Neurobiology of Aging, 33 (1), 209.e3-209.e8. (doi:10.1016/j.neurobiolaging.2011.08.005). (PMID:21925771)

Record type: Article

Abstract

We and others have recently reported an association between amyotrophic lateral sclerosis (ALS) and single nucleotide polymorphisms on chromosome 9p21 in several populations. Here we show that the associated haplotype is the same in all populations and that several families previously shown to have genetic linkage to this region also share this haplotype. The most parsimonious explanation of these data are that there is a single founder for this form of disease.

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Accepted/In Press date: 12 August 2011
Published date: January 2012
Organisations: Medical Education

Identifiers

Local EPrints ID: 398568
URI: http://eprints.soton.ac.uk/id/eprint/398568
DOI: doi:10.1016/j.neurobiolaging.2011.08.005
PURE UUID: fd68c08a-fe33-4d78-b505-904d22f4c88a
ORCID for Karen E. Morrison: ORCID iD orcid.org/0000-0003-0216-5717

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Date deposited: 26 Jul 2016 12:52
Last modified: 15 Mar 2024 01:36

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Contributors

Author: Kin Mok
Author: Bryan J. Traynor
Author: Jennifer Schymick
Author: Pentti J. Tienari
Author: Hannu Laaksovirta
Author: Terhi Peuralinna
Author: Liisa Myllykangas
Author: Adriano Chiò
Author: Aleksey Shatunov
Author: Bradley F. Boeve
Author: Adam L. Boxer
Author: Mariely DeJesus-Hernandez
Author: Ian R. Mackenzie
Author: Adrian Waite
Author: Nigel Williams
Author: Huw R. Morris
Author: Javier Simón-Sánchez
Author: John C. van Swieten
Author: Peter Heutink
Author: Gabriella Restagno
Author: Gabriele Mora
Author: Karen E. Morrison ORCID iD
Author: Pamela J. Shaw
Author: Pamela Sara Rollinson
Author: Ammar Al-Chalabi
Author: Rosa Rademakers
Author: Stuart Pickering-Brown
Author: Richard W. Orrell
Author: Michael A. Nalls
Author: John Hardy

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