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Phosphate glass fibre scaffolds: tailoring of the properties and enhancement of the bioactivity through mesoporous glass particles

Phosphate glass fibre scaffolds: tailoring of the properties and enhancement of the bioactivity through mesoporous glass particles
Phosphate glass fibre scaffolds: tailoring of the properties and enhancement of the bioactivity through mesoporous glass particles
Novel bone glass fibre scaffolds were developed by thermally bonding phosphate glass fibres belonging to the P2O5-CaO-Na2O-SiO2-MgO-K2O-TiO2 system (TiPS2.5 glass). Scaffolds with fibres of 85 or 110µm diameter were fabricated, showing compressive strength in the range of 2–3.5 MPa, comparable to that of the trabecular bone. The effect of different thermal treatments and fibre diameters and length on the final scaffold structure was investigated by means of micro-CT analysis. The change of the sintering time from 30 to 60 min led to a decrease in the scaffold overall porosity from 58 to 21 vol.% for the 85µm fibre scaffold and from 50 to 40 vol.% when increasing the sintering temperature from 490 to 50°C for the 110µm fibre scaffold. The 85µm fibres resulted in an increase of the scaffold overall porosity, increased pore size and lower trabecular thickness; the use of different fibre diameters allowed the fabrication of a scaffold showing a porosity gradient.

In order to impart bioactive properties to the scaffold, for the first time in the literature the introduction in these fibre scaffolds of a bioactive phase, a melt-derived bioactive glass (CEL2) powder or spray-dried mesoporous bioactive glass particles (SD-MBG) was investigated. The scaffold bioactivity was assessed through soaking in simulated body fluid. CEL2/glass fibre scaffold did not show promising results due to particle detachment from the fibres during soaking in simulated body fluid. Instead the use of mesoporous bioactive powders showed to be an effective way to impart bioactivity to the scaffold and could be further exploited in the future through the ability of mesoporous particles to act as systems for the controlled release of drugs.
0928-4931
570-580
Novajra, G.
f96ec804-d9af-47fe-af35-251df0890d3b
Boetti, N.G.
fc2534c7-0951-4731-9274-73d4cab64dee
Lousteau, J.
0758be5e-04e3-452f-81f9-7616cf4a3de3
Fiorilli, S.
effae607-9586-449d-a981-5a0241faf5f6
Milanese, D.
ecb96980-ac53-454f-b513-cc5e6470fe24
Vitale-Brovarone, C.
23309d5c-86e5-4d71-b8eb-c2fbbad9c517
Novajra, G.
f96ec804-d9af-47fe-af35-251df0890d3b
Boetti, N.G.
fc2534c7-0951-4731-9274-73d4cab64dee
Lousteau, J.
0758be5e-04e3-452f-81f9-7616cf4a3de3
Fiorilli, S.
effae607-9586-449d-a981-5a0241faf5f6
Milanese, D.
ecb96980-ac53-454f-b513-cc5e6470fe24
Vitale-Brovarone, C.
23309d5c-86e5-4d71-b8eb-c2fbbad9c517

Novajra, G., Boetti, N.G., Lousteau, J., Fiorilli, S., Milanese, D. and Vitale-Brovarone, C. (2016) Phosphate glass fibre scaffolds: tailoring of the properties and enhancement of the bioactivity through mesoporous glass particles. Materials Science and Engineering C, 67, 570-580. (doi:10.1016/j.msec.2016.05.048).

Record type: Article

Abstract

Novel bone glass fibre scaffolds were developed by thermally bonding phosphate glass fibres belonging to the P2O5-CaO-Na2O-SiO2-MgO-K2O-TiO2 system (TiPS2.5 glass). Scaffolds with fibres of 85 or 110µm diameter were fabricated, showing compressive strength in the range of 2–3.5 MPa, comparable to that of the trabecular bone. The effect of different thermal treatments and fibre diameters and length on the final scaffold structure was investigated by means of micro-CT analysis. The change of the sintering time from 30 to 60 min led to a decrease in the scaffold overall porosity from 58 to 21 vol.% for the 85µm fibre scaffold and from 50 to 40 vol.% when increasing the sintering temperature from 490 to 50°C for the 110µm fibre scaffold. The 85µm fibres resulted in an increase of the scaffold overall porosity, increased pore size and lower trabecular thickness; the use of different fibre diameters allowed the fabrication of a scaffold showing a porosity gradient.

In order to impart bioactive properties to the scaffold, for the first time in the literature the introduction in these fibre scaffolds of a bioactive phase, a melt-derived bioactive glass (CEL2) powder or spray-dried mesoporous bioactive glass particles (SD-MBG) was investigated. The scaffold bioactivity was assessed through soaking in simulated body fluid. CEL2/glass fibre scaffold did not show promising results due to particle detachment from the fibres during soaking in simulated body fluid. Instead the use of mesoporous bioactive powders showed to be an effective way to impart bioactivity to the scaffold and could be further exploited in the future through the ability of mesoporous particles to act as systems for the controlled release of drugs.

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Accepted/In Press date: 12 May 2016
e-pub ahead of print date: 16 May 2016
Published date: 1 October 2016
Organisations: Optoelectronics Research Centre

Identifiers

Local EPrints ID: 400775
URI: http://eprints.soton.ac.uk/id/eprint/400775
ISSN: 0928-4931
PURE UUID: 66e5e979-5987-4665-af75-ee89a86101b1

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Date deposited: 27 Sep 2016 09:38
Last modified: 15 Mar 2024 02:28

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Contributors

Author: G. Novajra
Author: N.G. Boetti
Author: J. Lousteau
Author: S. Fiorilli
Author: D. Milanese
Author: C. Vitale-Brovarone

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