Intact negative patterning in rats with fornix or combined perirhinal and postrhinal cortex lesions

Bussey, Timothy J., Dias, Rebecca, Redhead, Edward S., Pearce, John M., Muir, Janice L. and Aggleton, John P. (2000) Intact negative patterning in rats with fornix or combined perirhinal and postrhinal cortex lesions. Experimental Brain Research, 134, (4), 506-519. (doi:10.1007/s002210000481).


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It has been proposed that the hippocampal formation is necessary for the acquisition of tasks that require the use of configural representations for their solution, including spatial learning and negative patterning. Tests of this influential view have, however, yielded conflicting results. For example fornix or hippocampal lesions, which reliably impair spatial learning, do not reliably impair negative patterning. A problem in interpreting these results has been the lack of controls for factors such as over-responding, excitatory effects of reward, and the possibility of non-configural solutions. At the same time, other studies have pointed to a role in configural learning for parahippocampal regions such as the perirhinal cortex. The present experiments controlled for the above factors and revealed that neither lesions of the fornix nor of the perirhinal/postrhinal cortex in the rat had any effect on negative patterning, although subsequent tests of object and spatial memory demonstrated the functional efficacy of the lesions.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1007/s002210000481
Additional Information:
ISSNs: 0014-4819 (print)
Related URLs:
Keywords: hippocampus, negative patterning, object discrimination, autoshaping, inferotemporal cortex
Subjects: R Medicine > R Medicine (General)
Q Science > QP Physiology
B Philosophy. Psychology. Religion > BF Psychology
Divisions : University Structure - Pre August 2011 > School of Psychology > Division of Cognition
ePrint ID: 40232
Accepted Date and Publication Date:
Date Deposited: 18 Jul 2006
Last Modified: 31 Mar 2016 12:10

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