Design and synthesis of oligoamide-based double a-helix mimetics
Design and synthesis of oligoamide-based double a-helix mimetics
An extensive series of bis-oligobenzamides and bis-oligopyridylamides have been efficiently prepared and studied by X-ray analysis and computational methods. A modular synthesis led to double ?-helix mimics bearing between two and ten branched side-chains. The inter-helix angle and distance can be tuned by varying the length and rigidity of the spacer, thereby reproducing the recognition domains of a range of super-secondary structures.
3433-3445
Kulikov, Oleg V.
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Thompson, Sam
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Xu, Hai
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Incarvito, Christopher D.
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Scott, Richard T.W.
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Saraogi, Ishu
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Nevola, Laura
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Hamilton, Andrew D.
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June 2013
Kulikov, Oleg V.
bf20410c-70eb-4abb-926e-fce32c7db6aa
Thompson, Sam
99b7e34e-fe24-401c-b7b0-64e56cbbbcb1
Xu, Hai
9ce740d6-ca75-41d8-9d5c-e9edaadae5e0
Incarvito, Christopher D.
35ef4c2f-9684-4982-9402-0d0b978ab56c
Scott, Richard T.W.
b7c85907-eec6-46da-b268-b21c6f5ecb09
Saraogi, Ishu
42a07959-549a-443c-b126-02e468963352
Nevola, Laura
1fa6946c-9170-4c57-a3e7-6f126478a9da
Hamilton, Andrew D.
048a6c75-91bf-4555-ab12-ce885eee65dd
Kulikov, Oleg V., Thompson, Sam, Xu, Hai, Incarvito, Christopher D., Scott, Richard T.W., Saraogi, Ishu, Nevola, Laura and Hamilton, Andrew D.
(2013)
Design and synthesis of oligoamide-based double a-helix mimetics.
European Journal of Organic Chemistry, 2013 (17), .
(doi:10.1002/ejoc.201300363).
Abstract
An extensive series of bis-oligobenzamides and bis-oligopyridylamides have been efficiently prepared and studied by X-ray analysis and computational methods. A modular synthesis led to double ?-helix mimics bearing between two and ten branched side-chains. The inter-helix angle and distance can be tuned by varying the length and rigidity of the spacer, thereby reproducing the recognition domains of a range of super-secondary structures.
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e-pub ahead of print date: 23 May 2013
Published date: June 2013
Organisations:
Chemistry
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Local EPrints ID: 403605
URI: http://eprints.soton.ac.uk/id/eprint/403605
ISSN: 1434-193X
PURE UUID: af35db12-b9fd-4efb-b05a-cac47b66d4df
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Date deposited: 07 Dec 2016 11:35
Last modified: 15 Mar 2024 03:54
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Contributors
Author:
Oleg V. Kulikov
Author:
Hai Xu
Author:
Christopher D. Incarvito
Author:
Richard T.W. Scott
Author:
Ishu Saraogi
Author:
Laura Nevola
Author:
Andrew D. Hamilton
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