Design and synthesis of oligoamide-based double a-helix mimetics (Eur. J. Org. Chem. 17/2013)
Design and synthesis of oligoamide-based double a-helix mimetics (Eur. J. Org. Chem. 17/2013)
The cover picture shows the binding of transcription factors to nucleic acids. Top left: multicomponent protein; bottom right: leucine zipper; centre: bis-oligobenzamide peptidomimetic; background: DNA chains. The xanthene-linked bis-oligobenzamide shown in the centre is an example of a super-secondary structural protein mimic. This work details the synthesis of oligobenzamide and oligopyridylamide strands connected through various spacers, allowing tuning of the inter-helix angle and thus the potential nucleic acid or protein binding properties. Details are discussed in the article by A. D. Hamilton et al. on page 3427 ff.
Kulikov, Oleg V.
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Thompson, Sam
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Xu, Hai
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Incarvito, Christopher D.
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Scott, Richard T.W.
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Saraogi, Ishu
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Nevola, Laura
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Hamilton, Andrew D.
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June 2013
Kulikov, Oleg V.
bf20410c-70eb-4abb-926e-fce32c7db6aa
Thompson, Sam
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Xu, Hai
9ce740d6-ca75-41d8-9d5c-e9edaadae5e0
Incarvito, Christopher D.
35ef4c2f-9684-4982-9402-0d0b978ab56c
Scott, Richard T.W.
b7c85907-eec6-46da-b268-b21c6f5ecb09
Saraogi, Ishu
42a07959-549a-443c-b126-02e468963352
Nevola, Laura
1fa6946c-9170-4c57-a3e7-6f126478a9da
Hamilton, Andrew D.
048a6c75-91bf-4555-ab12-ce885eee65dd
Kulikov, Oleg V., Thompson, Sam, Xu, Hai, Incarvito, Christopher D., Scott, Richard T.W., Saraogi, Ishu, Nevola, Laura and Hamilton, Andrew D.
(2013)
Design and synthesis of oligoamide-based double a-helix mimetics (Eur. J. Org. Chem. 17/2013).
[in special issue: Foldamers]
European Journal of Organic Chemistry, 2013 (17).
(doi:10.1002/ejoc.201390045).
Abstract
The cover picture shows the binding of transcription factors to nucleic acids. Top left: multicomponent protein; bottom right: leucine zipper; centre: bis-oligobenzamide peptidomimetic; background: DNA chains. The xanthene-linked bis-oligobenzamide shown in the centre is an example of a super-secondary structural protein mimic. This work details the synthesis of oligobenzamide and oligopyridylamide strands connected through various spacers, allowing tuning of the inter-helix angle and thus the potential nucleic acid or protein binding properties. Details are discussed in the article by A. D. Hamilton et al. on page 3427 ff.
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Published date: June 2013
Organisations:
Chemistry
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Local EPrints ID: 403607
URI: http://eprints.soton.ac.uk/id/eprint/403607
ISSN: 1434-193X
PURE UUID: e85071a2-7fa6-46be-9085-976c28dd90ff
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Date deposited: 07 Dec 2016 13:24
Last modified: 15 Mar 2024 03:54
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Contributors
Author:
Oleg V. Kulikov
Author:
Hai Xu
Author:
Christopher D. Incarvito
Author:
Richard T.W. Scott
Author:
Ishu Saraogi
Author:
Laura Nevola
Author:
Andrew D. Hamilton
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