Aryl-linked imidazolidin-2-ones as non-peptidic beta-strand mimetics

Sutherell, Charlotte L., Thompson, Sam, Scott, Richard T.W. and Hamilton, Andrew D. (2012) Aryl-linked imidazolidin-2-ones as non-peptidic beta-strand mimetics. Chemical Communications, 48 (79), 9834-9836. (doi:10.1039/C2CC34791A).

Record type: Article

Abstract

We describe the design and synthesis of a non-peptidic beta-strand mimetic composed of alternating aryl and imidazolidin-2-one rings that can be adapted to display diverse side-chains. Solid- and solution-phase data together with calculations suggest that the desired conformation for side-chain mimicry is readily accessible and well-populated.

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Published date: 26 July 2012

Organisations: Chemistry

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Identifiers

Local EPrints ID: 403609

URI: http://eprints.soton.ac.uk/id/eprint/403609

DOI: doi:10.1039/C2CC34791A

ISSN: 1359-7345

PURE UUID: 228be823-9fb6-4d3a-be18-6e7d5a5c4a00

ORCID for Sam Thompson:

orcid.org/0000-0001-6267-5693

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Date deposited: 06 Dec 2016 16:43

Last modified: 15 Mar 2024 03:54

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Contributors

Author: Charlotte L. Sutherell

Author: Sam Thompson

Author: Richard T.W. Scott

Author: Andrew D. Hamilton

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