An exploratory study of the physiological correlates of neurodevelopmental delay in infants with sickle cell anaemia


Prengler, M., Kirkham, F.J, Hogan, A.M, Telfer, P., Lane, R., Vargha-Khadem, F. and De Haan, M. (2005) An exploratory study of the physiological correlates of neurodevelopmental delay in infants with sickle cell anaemia. British Journal of Haematology, 132, (1), 99-107. (doi:10.1111/j.1365-2141.2005.05828.x).

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Description/Abstract

This study aimed to investigate whether infants with sickle cell anaemia (SCA) are at risk of neurodevelopmental delay, and whether any delay is associated with SCA pathology. Twenty-eight infants (14 SCA; 14 age- and ethnic-similar controls) were assessed longitudinally with the Bayley Infant Neurodevelopmental Screener (BINS) at 3, 9 and 12 months. Transcranial Doppler (TCD) and pulse oximetry (SpO2) measures were recorded longitudinally in SCA infants, and a subgroup of controls. Haemoglobin values were obtained from SCA infants. At each age, SCA infants obtained BINS scores indicative of greater risk of neurodevelopmental delay compared with controls. The number of moderate–high BINS risk scores increased significantly between 3 and 9 months. At 9 months BINS raw scores correlated negatively with TCD velocity and positively with haemoglobin. This exploratory study suggests that SCA infants may be at greater risk of neurodevelopmental delay than previously considered, and may provide the impetus for further research into the very early precursors of cognitive impairment.

Item Type: Article
Additional Information:
ISSNs: 0007-1048 (print)
Related URLs:
Subjects: R Medicine > RB Pathology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
R Medicine > RJ Pediatrics > RJ101 Child Health. Child health services
Divisions: University Structure - Pre August 2011 > School of Psychology > Division of Clinical Neuroscience
ePrint ID: 40367
Date Deposited: 03 Jul 2006
Last Modified: 27 Mar 2014 18:25
Contact Email Address: A.Hogan@soton.ac.uk
URI: http://eprints.soton.ac.uk/id/eprint/40367

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