Maternal stress and psychological distress preconception:: association with offspring atopic eczema at age 12 months
Maternal stress and psychological distress preconception:: association with offspring atopic eczema at age 12 months
BACKGROUND: Perinatal maternal stress and low mood have been linked to offspring atopic eczema.
OBJECTIVES: To examine the relation of maternal stress/mood with atopic eczema in the offspring, focusing particularly on stress/psychological distress preconception.
METHODS: At recruitment in the UK Southampton Women's Survey, preconception maternal reports of perceived stress in daily living and the effect of stress on health were recorded; in a subsample, psychological distress was assessed (12-item General Health Questionnaire). Infants were followed up at ages 6 (n = 2956) and 12 (n = 2872) months and atopic eczema ascertained (based on UK Working Party Criteria for the Definition of Atopic Dermatitis). At 6 months post-partum, mothers were asked if they had experienced symptoms of low mood since childbirth and completed the Edinburgh Postnatal Depression Scale.
RESULTS: Preconception perceived stress affecting health [OR 1.21 (95% CI 1.08-1.35), P = 0.001] and stress in daily living [OR 1.16 (1.03-1.30), P = 0.014] were associated with an increased risk of offspring atopic eczema at age 12 months but not at 6 months, robust to adjustment for potentially confounding variables. Findings were similar for maternal psychological distress preconception. Low maternal mood between delivery and 6 months post-partum was associated with an increased risk of infantile atopic eczema at age 12 months, but no significant association between post-natal mood and atopic eczema was seen after taking account of preconception stress.
CONCLUSION AND CLINICAL RELEVANCE: Our data provide novel evidence linking maternal stress at preconception to atopic eczema risk, supporting a developmental contribution to the aetiology of atopic eczema and pointing to potentially modifiable influences.
Adult, Child, Child, Preschool, Dermatitis, Atopic, Female, Humans, Infant, Infant, Newborn, Mothers, Pregnancy, Prenatal Exposure Delayed Effects, Risk Factors, Stress, Psychological, Surveys and Questionnaires, Journal Article
760-769
El-Heis, S.
6d7d2e03-3d63-4510-8b7e-fcbe4653db13
Crozier, S. R.
9c3595ce-45b0-44fa-8c4c-4c555e628a03
Healy, E.
400fc04d-f81a-474a-ae25-7ff894be0ebd
Robinson, S. M.
ba591c98-4380-456a-be8a-c452f992b69b
Harvey, N. C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Inskip, H. M.
5fb4470a-9379-49b2-a533-9da8e61058b7
Baird, J.
f4bf2039-6118-436f-ab69-df8b4d17f824
Godfrey, K. M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Southampton Women's Study Group
June 2017
El-Heis, S.
6d7d2e03-3d63-4510-8b7e-fcbe4653db13
Crozier, S. R.
9c3595ce-45b0-44fa-8c4c-4c555e628a03
Healy, E.
400fc04d-f81a-474a-ae25-7ff894be0ebd
Robinson, S. M.
ba591c98-4380-456a-be8a-c452f992b69b
Harvey, N. C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Inskip, H. M.
5fb4470a-9379-49b2-a533-9da8e61058b7
Baird, J.
f4bf2039-6118-436f-ab69-df8b4d17f824
Godfrey, K. M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
El-Heis, S., Crozier, S. R., Healy, E., Robinson, S. M., Harvey, N. C., Cooper, C., Inskip, H. M., Baird, J. and Godfrey, K. M.
,
Southampton Women's Study Group
(2017)
Maternal stress and psychological distress preconception:: association with offspring atopic eczema at age 12 months.
Clinical & Experimental Allergy, 47 (6), .
(doi:10.1111/cea.12910).
Abstract
BACKGROUND: Perinatal maternal stress and low mood have been linked to offspring atopic eczema.
OBJECTIVES: To examine the relation of maternal stress/mood with atopic eczema in the offspring, focusing particularly on stress/psychological distress preconception.
METHODS: At recruitment in the UK Southampton Women's Survey, preconception maternal reports of perceived stress in daily living and the effect of stress on health were recorded; in a subsample, psychological distress was assessed (12-item General Health Questionnaire). Infants were followed up at ages 6 (n = 2956) and 12 (n = 2872) months and atopic eczema ascertained (based on UK Working Party Criteria for the Definition of Atopic Dermatitis). At 6 months post-partum, mothers were asked if they had experienced symptoms of low mood since childbirth and completed the Edinburgh Postnatal Depression Scale.
RESULTS: Preconception perceived stress affecting health [OR 1.21 (95% CI 1.08-1.35), P = 0.001] and stress in daily living [OR 1.16 (1.03-1.30), P = 0.014] were associated with an increased risk of offspring atopic eczema at age 12 months but not at 6 months, robust to adjustment for potentially confounding variables. Findings were similar for maternal psychological distress preconception. Low maternal mood between delivery and 6 months post-partum was associated with an increased risk of infantile atopic eczema at age 12 months, but no significant association between post-natal mood and atopic eczema was seen after taking account of preconception stress.
CONCLUSION AND CLINICAL RELEVANCE: Our data provide novel evidence linking maternal stress at preconception to atopic eczema risk, supporting a developmental contribution to the aetiology of atopic eczema and pointing to potentially modifiable influences.
Text
CEA El-Heis et al Maternal stress preconception and atopic eczema Revision1 140117
- Accepted Manuscript
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Maternal stress preconception and atopic eczema fig 1
- Accepted Manuscript
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Maternal stress preconception and atopic eczmea fig 2
- Accepted Manuscript
More information
Accepted/In Press date: 9 February 2017
e-pub ahead of print date: 17 March 2017
Published date: June 2017
Keywords:
Adult, Child, Child, Preschool, Dermatitis, Atopic, Female, Humans, Infant, Infant, Newborn, Mothers, Pregnancy, Prenatal Exposure Delayed Effects, Risk Factors, Stress, Psychological, Surveys and Questionnaires, Journal Article
Organisations:
Medical Research Council, Human Development & Health, Clinical & Experimental Sciences
Identifiers
Local EPrints ID: 406268
URI: http://eprints.soton.ac.uk/id/eprint/406268
ISSN: 0954-7894
PURE UUID: cf36f43f-d5c4-49c7-bd00-9121f65bd059
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Date deposited: 10 Mar 2017 10:43
Last modified: 18 Mar 2024 05:09
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Contributors
Author:
S. El-Heis
Author:
S. M. Robinson
Corporate Author: Southampton Women's Study Group
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