Compound optimal designs for percentile estimation in dose-response models with restricted design intervals


Biedermann, Stefanie, Dette, Holger and Zhu, Wei (2005) Compound optimal designs for percentile estimation in dose-response models with restricted design intervals. In, Ermakov, S.M., Melas, V.B. and Pepelyshev, A.N. (eds.) Proceedings of the 5th St. Petersburg Workshop on Simulation. The Fifth Workshop on Simulation St.Petersburg, Russia, St. Petersburg State University, 143-148.

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Description/Abstract

In dose-response studies, the dose range is often restricted due to ethics concerns over drug toxicity and/or efficacy,
particularly when human subjects are involved. We present locally optimal designs for the estimation of several percentiles simultaneously on restricted as well as unrestricted design intervals. Our results hold true for most of the commonly applied link functions with respect to the model under consideration.

Item Type: Book Section
Keywords: Dose-response model; link function; percentile estimation; compound optimal design; A-optimality
Subjects: Q Science > QA Mathematics
H Social Sciences > HA Statistics
Divisions: University Structure - Pre August 2011 > School of Mathematics > Statistics
ePrint ID: 41828
Date Deposited: 06 Oct 2006
Last Modified: 27 Mar 2014 18:26
URI: http://eprints.soton.ac.uk/id/eprint/41828

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