Compound optimal designs for percentile estimation in dose-response models with restricted design intervals
Biedermann, Stefanie, Dette, Holger and Zhu, Wei (2005) Compound optimal designs for percentile estimation in dose-response models with restricted design intervals. In, Ermakov, S.M., Melas, V.B. and Pepelyshev, A.N. (eds.) Proceedings of the 5th St. Petersburg Workshop on Simulation. The Fifth Workshop on Simulation St.Petersburg, Russia, St. Petersburg State University, 143-148.
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Description/Abstract
In dose-response studies, the dose range is often restricted due to ethics concerns over drug toxicity and/or efficacy,
particularly when human subjects are involved. We present locally optimal designs for the estimation of several percentiles simultaneously on restricted as well as unrestricted design intervals. Our results hold true for most of the commonly applied link functions with respect to the model under consideration.
| Item Type: | Book Section |
|---|---|
| Keywords: | Dose-response model; link function; percentile estimation; compound optimal design; A-optimality |
| Subjects: | Q Science > QA Mathematics H Social Sciences > HA Statistics |
| Divisions: | University Structure - Pre August 2011 > School of Mathematics > Statistics |
| Item ID: | 41828 |
| Date Deposited: | 06 Oct 2006 |
| Last Modified: | 28 Jun 2012 10:41 |
| Contributors: | Biedermann, Stefanie (Author) Dette, Holger (Author) Zhu, Wei (Author) Ermakov, S.M. (Editor) Melas, V.B. (Editor) Pepelyshev, A.N. (Editor) |
| Date: | July 2005 |
| Status: | Published |
| Publisher: | St. Petersburg State University |
| URI: | http://eprints.soton.ac.uk/id/eprint/41828 |
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