Biedermann, Stefanie, Dette, Holger and Zhu, Wei
Compound optimal designs for percentile estimation in dose-response models with restricted design intervals.
Ermakov, S.M., Melas, V.B. and Pepelyshev, A.N. (eds.)
Proceedings of the 5th St. Petersburg Workshop on Simulation.
The Fifth Workshop on Simulation
St. Petersburg State University.
In dose-response studies, the dose range is often restricted due to ethics concerns over drug toxicity and/or efficacy,
particularly when human subjects are involved. We present locally optimal designs for the estimation of several percentiles simultaneously on restricted as well as unrestricted design intervals. Our results hold true for most of the commonly applied link functions with respect to the model under consideration.
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