2B or not 2B, that is the question: further investigations into the use of pencil as a matrix for matrix-assisted laser desorption/ionisation


Langley, G.J., Herniman, J.M. and Townell, M.S. (2007) 2B or not 2B, that is the question: further investigations into the use of pencil as a matrix for matrix-assisted laser desorption/ionisation. Rapid Communications in Mass Spectrometry, 21, (2), 180-190. (doi:10.1002/rcm.2827).

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Original Publication URL: http://dx.doi.org/10.1002/rcm.2827

Description/Abstract

The effective use of pencil as a matrix for matrix-assisted laser desorption/ionisation (MALDI) for the study of actinides has previously been demonstrated (Black et al., Rapid Commun. Mass Spectrom. 2006; 20: 1053). Here, the scope of the types of molecules amenable to analysis by this method has been extended, establishing that 90% of a library containing 50 diverse small molecules can be successfully analysed by this technique. Further, the role played by the bulk materials present in the different pencil leads has been investigated and a simple one-step deposition of matrix and calibration materials has been achieved through the fabrication of different calibration pencils (Cali-Pens)

Item Type: Article
ISSNs: 0951-4198 (print)
Related URLs:
Keywords: Mass spectrometry, MALDI matrix, pencil matrix, MALDI
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Divisions: University Structure - Pre August 2011 > School of Chemistry
ePrint ID: 44150
Date Deposited: 16 Feb 2007
Last Modified: 27 Mar 2014 18:28
Contact Email Address: gjl@soton.ac.uk
URI: http://eprints.soton.ac.uk/id/eprint/44150

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