Anthropometry, glucose tolerance, and insulin concentrations in Indian children

Krishnaveni, Ghattu V., Hill, Jacqueline C., Leary, Samantha D., Veena, Sargoor R., Saperia, Julia, Saroja, Anandathirtha, Karat, Samuel C. and Fall, Caroline H.D. (2005) Anthropometry, glucose tolerance, and insulin concentrations in Indian children. Diabetes Care, 28, (12), 2919-2925. (doi:10.2337/diacare.28.12.2919).


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OBJECTIVE: The purpose of this study was to test the hypothesis that the environment experienced by fetuses of mothers with gestational diabetes mellitus (GDM) and mothers with higher glucose concentrations that are in the normal range causes increased adiposity and altered glucose/insulin metabolism in childhood. RESEARCH DESIGN AND METHODS: Children (n = 630) whose mothers were tested for glucose tolerance during pregnancy had detailed anthropometry performed at birth and annually thereafter. At 5 years, plasma glucose and insulin concentrations were measured in the children (2-h oral glucose tolerance test) and their fathers (fasting samples only). RESULTS: Newborns of diabetic mothers (n = 41) were larger in all body measurements than control newborns (babies with nondiabetic parents). At 1 year, these differences had diminished and were not statistically significant. At 5 years, female offspring of diabetic mothers had larger subscapular and triceps skinfold thicknesses (P = 0.01) and higher 30- and 120-min insulin concentrations (P < 0.05) than control children. Offspring of diabetic fathers (n = 41) were lighter at birth than control children (P < 0.001); they showed no differences in anthropometry at 5 years. In control children, skinfold thickness and 30-min insulin concentrations were positively related to maternal insulin area under the curve, and skinfold thicknesses were related to paternal fasting insulin concentrations independently of the parents' skinfold thickness and socioeconomic status. CONCLUSIONS: Maternal GDM is associated with adiposity and higher glucose and insulin concentrations in female offspring at 5 years. The absence of similar associations in offspring of diabetic fathers suggests a programming effect in the diabetic intrauterine environment. More research is needed to determine whether higher maternal glucose concentrations in the nondiabetic range have similar effects

Item Type: Article
Digital Object Identifier (DOI): doi:10.2337/diacare.28.12.2919
ISSNs: 0149-5992 (print)
Related URLs:
Keywords: adult, aging, anthropometry, birth, blood, blood glucose, body height, body weight, child, childhood, design, diabetes, embryonic development, environment, ethnology, fathers, female, glucose, glucose tolerance, glucose tolerance test, great britain, humans, hypothesis, india, insulin, insulin resistance, male, maternal age, metabolism, methods, mothers, parents, physiology, plasma, pregnancy, skinfold thickness
Subjects: H Social Sciences > HT Communities. Classes. Races
R Medicine > RB Pathology
R Medicine > RJ Pediatrics > RJ101 Child Health. Child health services
Divisions : University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
ePrint ID: 44179
Accepted Date and Publication Date:
December 2005Published
Date Deposited: 20 Feb 2007
Last Modified: 31 Mar 2016 12:17

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