Combined effects of dietary fat and birth weight on serum cholesterol concentrations: the Hertfordshire Cohort Study

Robinson, Sian M., Batelaan, Sue F., Syddall, Holly E., Aihie Sayer, Avan, Dennison, Elaine M., Martin, Helen J., Barker, David J. and Cooper, Cyrus, the Hertfordshire Cohort Study Group (2006) Combined effects of dietary fat and birth weight on serum cholesterol concentrations: the Hertfordshire Cohort Study. American Journal of Clinical Nutrition, 84, (1), 237-244.


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BACKGROUND: Blood cholesterol responses to the manipulation of dietary fat vary widely between persons. Although epidemiologic evidence suggests that prenatal growth and nutrition influence adult cholesterol homeostasis, whether prenatal growth modifies the association between dietary fat intake and serum cholesterol concentration in adults is unknown.

OBJECTIVE: The aim was to examine the relation between fat intake and serum cholesterol concentrations in men and women whose birth weights were known. DESIGN: We studied a cohort of men and women aged 59-71 y. Diet was assessed with a food-frequency questionnaire. Total, HDL-, and LDL-cholesterol concentrations and the ratio of HDL to LDL cholesterol were measured in fasting blood samples from 574 men and 562 women who did not have coronary heart disease.

RESULTS: Total and saturated fat intakes were not associated with serum cholesterol concentrations in men or women. However, subdivision by birth weight showed associations in men but not in women. High intakes of total and saturated fat were associated with reduced HDL-cholesterol concentrations in men with birth weights < or =3.2 kg (7 lb) but not in men with higher birth weights. Similar effects on the HDL-to-LDL cholesterol ratio were observed (P for interaction = 0.02 for total fat and 0.01 for saturated fat). When 32 men taking cholesterol-lowering medication were excluded, the interactions were strengthened (P = 0.008 and 0.006, respectively).

CONCLUSION: The adverse effects of high intakes of total and saturated fat on serum cholesterol concentrations in men may be confined to those with lower birth weights.

Item Type: Article
Additional Information: Original research communication
ISSNs: 0002-9165 (print)
Related URLs:
Keywords: administration & dosage, adult, adverse effects, aged, anticholesteremic agents, birth, birth weight, blood, cholesterol, cholesterol hdl, cholesterol ldl, cohort, cohort studies, coronary heart disease, design diet, dietary fats, disease, epidemiology, fasting, female, growth, heart, hertfordshire, homeostasis, humans, linear models, male, metabolism, middle aged, nutrition, physiology, prospective studies, questionnaires, sex factors, therapeutic use, weight, women
Subjects: H Social Sciences > HT Communities. Classes. Races
R Medicine > RB Pathology
R Medicine > RG Gynecology and obstetrics
Divisions : University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
ePrint ID: 44237
Accepted Date and Publication Date:
July 2006Published
Date Deposited: 21 Feb 2007
Last Modified: 31 Mar 2016 12:18

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